The anticandidal properties of chlorinated 8-quinolinols

The in vitro anticandidal properties of six chlorinated 8-quinolinols (3-chloro-, 5-chloro-, 6-chloro-, 7-chloro-, 3,6-dichloro-, and 5,7-dichloro-8-quinolinols) were evaluated. Various concentrations of these compounds were added to cultures of Candida albicans and C. tropicalis grown in Sabouraud...

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Bibliographic Details
Published in:Mycologia 1996-07, Vol.88 (4), p.651-654
Main Authors: Lentz, D.L. (The New York Botanical Garden, Bronx, NY.), Gershon, H, Marini, H, Century, G.A
Format: Article
Language:English
Subjects:
AIDS
antifungal agents
Antifungals
Azoles
baby hamster kidney (BHK) cells
Botanical gardens
CANDIDA
Candida albicans
Candida tropicalis
Cell growth
chloro-8-quinolinols
COMPOSE ORGANOCHLORE
COMPUESTO ORGANICO DEL CLORO
CONTROL DE ENFERMEDADES
CONTROLE DE MALADIES
Cytotoxicity
DISEASE CONTROL
DOSAGE EFFECTS
FONGICIDE
FUNGICIDAS
FUNGICIDES
HALOGENATED HYDROCARBONS
HIDROCARBUROS HALOGENADOS
HYDROCARBURE HALOGENE
Hydroxyquinolines
Kidneys
ORGANOCHLORINE COMPOUNDS
Physiology/Biochemistry
Plant growth
QUINONAS
QUINONE
QUINONES
Yeasts
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Summary:The in vitro anticandidal properties of six chlorinated 8-quinolinols (3-chloro-, 5-chloro-, 6-chloro-, 7-chloro-, 3,6-dichloro-, and 5,7-dichloro-8-quinolinols) were evaluated. Various concentrations of these compounds were added to cultures of Candida albicans and C. tropicalis grown in Sabouraud dextrose broth with and without bovine serum. The 5-chloro- and 6-chloro-8-quinolinols proved to be most effective at inhibiting the growth of C. albicans while 3,6-dichloro-8-quinolinol was most effective at controlling the growth of C. tropicalis. Cytotoxicity tests on baby hamster kidney (BHK) cells, however, demonstrated that the compounds tested were cytotoxic at their minimum inhibitory concentrations except for 3,6-dichloro-8-quinolinol which proved effective at inhibiting the growth of C. tropicalis at about one half the cytotoxic dose. Because this compound showed antifungal properties at concentrations that do not suppress mammalian cell growth, it merits further investigation as a possible topical or systemic anticandidal agent.
ISSN:0027-5514
1557-2536
DOI:10.1080/00275514.1996.12026699