Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases

Abstract Cell secreted exosomes (30–100 nm vesicles) play a major role in intercellular communication due to their ability to transfer proteins and nucleic acids from one cell to another. Depending on the originating cell type and the cargo, exosomes can have immunosuppressive or immunostimulatory e...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2015-09, Vol.160 (1), p.46-58
Main Authors: Tran, Thanh-Huyen, Mattheolabakis, George, Aldawsari, Hibah, Amiji, Mansoor
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigen-Presenting Cells - immunology
Autoimmune diseases
Autoimmune Diseases - therapy
Cancer
Drug Carriers
Exosomes
Humans
Immunotherapy
Immunotherapy - methods
Inflammation - therapy
Nanocarrier
Neoplasms - therapy
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Summary:Abstract Cell secreted exosomes (30–100 nm vesicles) play a major role in intercellular communication due to their ability to transfer proteins and nucleic acids from one cell to another. Depending on the originating cell type and the cargo, exosomes can have immunosuppressive or immunostimulatory effects, which have potential application as immunotherapies for cancer and autoimmune diseases. Cellular components shed from tumor cells or antigen presenting cells (APCs), such as dendritic cells, macrophages and B cells, have been shown to be efficiently packaged in exosomes. In this review, we focus on the application of exosomes as nanocarriers and immunological agents for cancer and autoimmune immunotherapy. APC-derived exosomes demonstrate effective therapeutic efficacy for the treatment of cancer and experimental autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. In addition to their intrinsic immunomodulating activity, exosomes have many advantages over conventional nanocarriers for drug and gene delivery.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2015.03.021