Prenatal stress induces vulnerability to nicotine addiction and alters D2 receptors’ expression in the nucleus accumbens in adult rats

Highlights • Nicotine induces CPP in rats at the dose of 0.5 mg/kg. • Prenatal stress intensifies nicotine-induced CPP in adult rats. • Prenatal Stress increases DRD2 expression levels in the nucleus accumbens. • DRD2 expression is downregulated in the nicotine-treated prenatally stressed rats....

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Bibliographic Details
Published in:Neuroscience 2015-09, Vol.304, p.279-285
Main Authors: Said, N, Lakehayli, S, El Khachibi, M, El Ouahli, M, Nadifi, S, Hakkou, F, Tazi, A
Format: Article
Language:English
Subjects:
Animals
conditioned place preference
Conditioning (Psychology) - drug effects
Conditioning (Psychology) - physiology
Disease Models, Animal
DRD2 mRNA expression
Female
Male
Neurology
nicotine
Nicotine - administration & dosage
Nicotinic Agonists - administration & dosage
nucleus accumbens
Nucleus Accumbens - drug effects
Nucleus Accumbens - growth & development
Nucleus Accumbens - metabolism
Polymerase Chain Reaction
Pregnancy
Prenatal Exposure Delayed Effects
prenatal stress
qPCR
Rats, Wistar
Receptors, Dopamine D2 - metabolism
RNA, Messenger - metabolism
Spatial Behavior - drug effects
Spatial Behavior - physiology
Stress, Psychological - physiopathology
Tobacco Use Disorder - physiopathology
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Summary:Highlights • Nicotine induces CPP in rats at the dose of 0.5 mg/kg. • Prenatal stress intensifies nicotine-induced CPP in adult rats. • Prenatal Stress increases DRD2 expression levels in the nucleus accumbens. • DRD2 expression is downregulated in the nicotine-treated prenatally stressed rats.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.07.029