Topological conflicts in phylogenetic analysis of different regions of the sable (Martes zibellina L.) mitochondrial genome

• Published in: Russian journal of genetics 2015-08, Vol.51 (8), p.783-790
• Main Authors: Malyarchuk, B. A, Derenko, M. V, Denisova, G. A, Litvinov, A. N
• Format: Article
• Language: English
• Subjects: Animal Genetics; Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; carbon dioxide; genes; haplotypes; Human Genetics; Martes; Martes zibellina; Microbial Genetics and Genomics; mitochondrial DNA; mitochondrial genome; mutation; phylogeny; ribosomal RNA; topology
• ISSN: 1022-7954; 1608-3369
• DOI: 10.1134/S1022795415060095

Phylogenetic analysis of different regions of the mitochondrial genome of the sable showed the presence of several topologies of phylogenetic trees, but the most statistically significant topology is A-BC, which was obtained as a result of the analysis of the mitochondrial genome as a whole, as well as of the individual CO1, ND4, and ND5 genes. Analysis of the intergroup divergence of the mtDNA haplotypes (D ₓy) indicated that the maximum D ₓy values between A and BC groups were accompanied by minimum differences between B and C groups only for six genes showing the A-BC topology (12S rRNA, CO1, CO2, ND4, ND5, and CYTB). It is assumed that the topological conflicts observed in the analysis of individual sable mtDNA genes are associated with the uneven distribution of mutations along the mitochondrial genome and the mitochondrial tree. This may be due to random causes, as well as the nonuniform effect of selection.