Quantitative EEG and Current Source Density Analysis of Combined Antiepileptic Drugs and Dopaminergic Agents in Genetic Epilepsy: Two Case Studies

Two adolescent females with absence epilepsy were classified, one as attention deficit and the other as bipolar disorder. Physical and cognitive exams identified hypotension, bradycardia, and cognitive dysfunction. Their initial electroencephalograms (EEGs) were considered slightly slow, but within...

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Bibliographic Details
Published in:Clinical EEG and neuroscience 2015-07, Vol.46 (3), p.256-262
Main Authors: Emory, Hamlin, Wells, Christopher, Mizrahi, Neptune
Format: Article
Language:English
Subjects:
Adolescent
Anticonvulsants - administration & dosage
Authorship
Dopamine
Dopamine Agents - administration & dosage
Drug dosages
Drug Monitoring - methods
Drug Therapy, Combination - methods
Electroencephalography
Electroencephalography - drug effects
Electroencephalography - methods
Epilepsy
Epilepsy - diagnosis
Epilepsy - drug therapy
Epilepsy - genetics
Female
Humans
Insomnia
Mental Disorders - diagnosis
Mental Disorders - drug therapy
Mental Disorders - genetics
Patients
Studies
Treatment Outcome
Young Adult
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Summary:Two adolescent females with absence epilepsy were classified, one as attention deficit and the other as bipolar disorder. Physical and cognitive exams identified hypotension, bradycardia, and cognitive dysfunction. Their initial electroencephalograms (EEGs) were considered slightly slow, but within normal limits. Quantitative EEG (QEEG) data included relative theta excess and low alpha mean frequencies. A combined treatment of antiepileptic drugs with a catecholamine agonist/reuptake inhibitor was sequentially used. Both patients’ physical and cognitive functions improved and they have remained seizure free. The clinical outcomes were correlated with statistically significant changes in QEEG measures toward normal Z-scores in both anterior and posterior regions. In addition, low resolution electromagnetic tomography (LORETA) Z-scored source correlation analyses of the initial and treated QEEG data showed normalized patterns, supporting a neuroanatomic resolution. This study presents preliminary evidence for a neurophysiologic approach to patients with absence epilepsy and comorbid disorders and may provide a method for further research.
ISSN:1550-0594
2169-5202
DOI:10.1177/1550059414532253