Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types

Papillomaviruses are small and complex viruses that belong to the Papillomaviridae family, which comprises 39 genera. The bovine papillomavirus (BPV) causes an infectious disease that is characterized by chronic and proliferative benign tumors that affect cattle worldwide. Different genotypes of BPV...

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Bibliographic Details
Published in:Virus genes 2015-08, Vol.51 (1), p.77-84
Main Authors: da Silva, Flavio R. C., Daudt, Cíntia, Streck, André F., Weber, Matheus N., Filho, Ronaldo V. Leite, Driemeier, David, Canal, Cláudio W.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Bovine papillomavirus
Brazil
Capsid Proteins - genetics
Cattle
Cattle Diseases - pathology
Cattle Diseases - virology
Cluster Analysis
DNA, Viral - chemistry
DNA, Viral - genetics
Genetic Variation
Genotype
Histocytochemistry
Medical Microbiology
Microscopy
Papillomaviridae - classification
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - pathology
Papillomavirus Infections - veterinary
Papillomavirus Infections - virology
Phylogeny
Plant Sciences
Sequence Analysis, DNA
Sequence Homology
Skin - pathology
Virology
Warts - pathology
Warts - veterinary
Warts - virology
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Summary:Papillomaviruses are small and complex viruses that belong to the Papillomaviridae family, which comprises 39 genera. The bovine papillomavirus (BPV) causes an infectious disease that is characterized by chronic and proliferative benign tumors that affect cattle worldwide. Different genotypes of BPVs can cause distinct skin and mucosal lesions and the immunity they raise has low cross-protection. This report aimed to genotype BPVs in cattle from Northern Brazil based on nucleotide partial sequences of the L1 ORF. Skin wart samples from 39 bovines clinically and histopathologically diagnosed as cutaneous papillomatosis from Acre and Rondônia States were analyzed. The results revealed four already reported BPV types (BPVs 1, 2, 11, and 13), nine putative new BPV subtypes and four putative new BPV types as well as two putative new BPV types that were already reported. To our knowledge, this is the first record of BPVs from the Brazilian Amazon region that identified new possible BPV types and subtypes circulating in this population. These findings point to the great genetic diversity of BPVs that are present in this region and highlight the importance of this knowledge before further studies about vaccination are attempted.
ISSN:0920-8569
1572-994X
DOI:10.1007/s11262-015-1220-y