Endogenous TGF beta 1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats

Transforming growth factor- beta 1 (TGF beta 1) has a diverse role in astrogliosis and neuronal survival, but the underlying mechanism remains to be elucidated, especially in traumatic brain injury (TBI). Here, we show that the expression of TGF beta 1 was increased in the pericontusional region, ac...

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Published in:Neurochemical research 2015-08, Vol.40 (8), p.1671-1680
Main Authors: Wang, Xu-Yang, Ba, Ying-Chun, Xiong, Liu-Lin, Li, Xiao-li, Zou, Yu, Zhu, Ye-Chun, Zhou, Xin-Fu, Wang, Ting-Hua, Wang, Fang, Tian, Heng-Li, Li, Jin-Tao
Format: Article
Language:English
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Summary:Transforming growth factor- beta 1 (TGF beta 1) has a diverse role in astrogliosis and neuronal survival, but the underlying mechanism remains to be elucidated, especially in traumatic brain injury (TBI). Here, we show that the expression of TGF beta 1 was increased in the pericontusional region, accompanied with astrogliosis and neuronal loss in TBI rats. Moreover, TGF beta 1 knockdown not only reduced the number of neurons and inhibited astrogliosis but also resulted in a significant neurological dysfunction in rats with TBI. Subsequently, Smad3, a key downstream signal of TGF beta 1, was involved in pericontusional region after TBI. These findings therefore indicate that TGF beta 1 is involved in neuroprotection and astrogliosis, via activation of down stream Smad3 signal in the brain after injury.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-015-1634-x