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Functional connectivity between right and left mesial temporal structures

The aim of this study is to investigate functional connectivity between right and left mesial temporal structures using cerebrocerebral evoked potentials. We studied seven patients with drug-resistant focal epilepsy who were explored with stereotactically implanted depth electrodes in bilateral hipp...

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Bibliographic Details
Published in:Brain Structure and Function 2015-09, Vol.220 (5), p.2617-2623
Main Authors: Lacuey, Nuria, Zonjy, Bilal, Kahriman, Emine S., Kaffashi, Farhad, Miller, Jonathan, Lüders, Hans O.
Format: Article
Language:English
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Summary:The aim of this study is to investigate functional connectivity between right and left mesial temporal structures using cerebrocerebral evoked potentials. We studied seven patients with drug-resistant focal epilepsy who were explored with stereotactically implanted depth electrodes in bilateral hippocampi. In all patients cerebrocerebral evoked potentials evoked by stimulation of the fornix were evaluated as part of a research project assessing fornix stimulation for control of hippocampal seizures. Stimulation of the fornix elicited responses in the ipsilateral hippocampus in all patients with a mean latency of 4.6 ms (range 2–7 ms). Two patients (29 %) also had contralateral hippocampus responses with a mean latency of 7.5 ms (range 5–12 ms) and without involvement of the contralateral temporal neocortex or amygdala. This study confirms the existence of connections between bilateral mesial temporal structures in some patients and explains seizure discharge spreading between homotopic mesial temporal structures without neocortical involvement.
ISSN:1863-2653
1863-2661
0340-2061
DOI:10.1007/s00429-014-0810-0