Can apical ballooning cardiomyopathy and anterior STEMI be differentiated based on β1 and β2-adrenergic receptors polymorphisms?

• Published in: International journal of cardiology 2015-11, Vol.199, p.189-192
• Main Authors: Vriz, Olga, Minisini, Rosalba, Zito, Concetta, Boccato, Elisa, Fimiani, Fabio, Pirisi, Mario, Facciolo, Caterina, Limongelli, Giuseppe, Bossone, Eduardo, Calabrò, Paolo
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Cardiomyopathies - genetics; Cardiomyopathies - pathology; Cardiovascular; Cardiovascular Diseases - genetics; Cardiovascular Diseases - pathology; Coronary Artery Disease - complications; Coronary Artery Disease - etiology; Diagnosis, Differential; European Continental Ancestry Group - genetics; Female; Genotype; Humans; Male; Middle Aged; Myocardial Infarction - genetics; Myocardial Infarction - pathology; Polymorphism, Single Nucleotide - genetics; Receptors, Adrenergic, beta-1 - genetics; Receptors, Adrenergic, beta-2 - genetics; Risk Factors; ST-elevation myocardial infarction; Tako-tsubo cardiomyopathy; Takotsubo Cardiomyopathy - genetics; Takotsubo Cardiomyopathy - pathology; Takotsubo Cardiomyopathy - physiopathology; β-Adrenoceptor polymorphisms
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2015.07.054

Abstract Aim Catecholamine excess along with an exaggerated sympathetic stimulation appears to play a major role in the pathophysiological mechanism of tako-tsubo cardiomyopathy (TTC), which mimics acute ST-elevation myocardial infarction (STEMI). The aim of the present study was to investigate differences in the distribution of allelic variants of β1- and β2-adrenoceptors between TTC and anterior STEMI patients compared to normal subjects. Methods and results β1- and/or β2-adrenoceptor polymorphisms in 97 patients with TTC (92 females, 96%; mean age 66.8 ± 11.6 years; range 35 to 87 years) were compared with 81 patients with anterior STEMI (77 females, 95%; mean age 72.5 ± 12.8 years; range 32 to 96 years) and 101 controls (95 females, 94%; mean age 62.3 ± 10.4 years; range 44 to 92 years). Differences in genotype frequencies were assessed using the Pearson χ2 test. β1-Adrenoceptor (Gly389Arg) and β2-adrenoceptor (Arg16Gly and Gln27Glu) genotype frequencies were significantly different among groups (p < 0.001, p = 0.024, p = 0.008, respectively). However, differences did not achieve statistical significance when TTC and anterior STEMI patients were compared by post-hoc analysis. The cardiovascular risk factor profile was worse in anterior STEMI patients, who more often had a history of systemic arterial hypertension, diabetes and coronary artery disease. Conclusions In a large TTC cohort compared with anterior STEMI patients, β-adrenoceptor polymorphisms were similar. However, the cardiovascular risk factor profile was different between the two groups. β-Adrenoceptor polymorphisms in TTC patients differed from normal subjects.