Exposure Assessment for a Study of Workers Exposed to Acrylonitrile

Procedures used to develop estimates of exposure to acrylonitrile for a cohort study (> 25 000 workers in 8 monomer, fiber, and resin companies from 1952 to 1983) are presented. Visits to the companies were made, interviews of workers were conducted, historical records were made, and measurements...

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Bibliographic Details
Published in:Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1998-01, Vol.24 (2), p.42-53
Main Authors: Stewart, Patricia A, Zaebst, Dennis, Zey, John N, Herrick, Robert, Dosemeci, Mustafa, Hornung, Richard, Bloom, Thomas, Pottern, Linda, Miller, Barry A, Blair, Aaron
Format: Article
Language:English
Subjects:
Acrylonitrile - analysis
Adult
Aged
Chemical engineering
Chemical hazards
Chemical Industry - statistics & numerical data
Cohort Studies
Determinism
Environmental Monitoring - methods
Environmental Monitoring - statistics & numerical data
Environmental Pollution - analysis
Environmental Pollution - statistics & numerical data
Estimate reliability
Estimation methods
Female
Humans
Industrial hygiene
Job titles
Male
Middle Aged
Monomers
Occupational Exposure - adverse effects
Occupational Exposure - statistics & numerical data
Occupational Health - statistics & numerical data
Occupations - statistics & numerical data
Odors
Quality Control
Risk Assessment
Sensitivity and Specificity
Time Factors
United States
Workplace - statistics & numerical data
Workplaces
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Summary:Procedures used to develop estimates of exposure to acrylonitrile for a cohort study (> 25 000 workers in 8 monomer, fiber, and resin companies from 1952 to 1983) are presented. Visits to the companies were made, interviews of workers were conducted, historical records were made, and measurements were taken. On the basis of similar tasks, locations, other exposures, and a similar distribution of exposures to acrylonitrile, 3600 exposure groups were formed. Special procedures were used to reduce the misclassification of workers performing tasks that varied in time but that were inadequately reflected in the job title. A software program organized and retained all exposure information on each exposure group. Quantitative estimates of acrylonitrile exposure were developed using a hierarchical approach in a software program that documented the derivation of each estimate and facilitated data review. Two of the estimation methods were evaluated in a comparison with measurement data.
ISSN:0355-3140
1795-990X