Pattern of Gross Congenital Malformations in a Tertiary Referral Hospital in Northeast India

• Published in: Indian journal of pediatrics 2015-10, Vol.82 (10), p.917-922
• Main Authors: Baruah, Jenita, Kusre, Giriraj, Bora, Reeta
• Format: Article
• Language: English
• Subjects: Congenital Abnormalities - epidemiology; Cross-Sectional Studies; Female; Gynecology; Humans; India - epidemiology; Infant, Newborn; Male; Medicine; Medicine & Public Health; Original Article; Pediatrics; Prevalence; Stillbirth; Tertiary Care Centers - statistics & numerical data
• ISSN: 0019-5456; 0973-7693
• DOI: 10.1007/s12098-014-1685-z

Objective To explore the prevalence of structural congenital malformations among newborns and study some of the fetal and maternal characteristics of the malformed babies in North east India where such systematic study on congenital malformation has not been undertaken before. Methods A cross sectional study was undertaken from May 2010 through Feb 2013 for estimation of gross congenital malformations among live birth and stillbirth children born in Assam Medical College. All live births were clinically examined for detection of gross congenital malformations and autopsy was carried out on still births and neonates dying within 24 h of birth to detect gross congenital malformations in the internal organs. All malformations were classified as per ICD 10 classification. The mothers of the newborns with congenital malformations were interviewed in a predesigned, pretested proforma. The variables included maternal age, antenatal registration, antenatal history of drug intake, consanguinity and previous history of malformations. Statistical analysis was done using chi square test. Results A total 18,192 births including live births and still births were examined and 206 cases of structural malformations were observed. Prevalence of congenital malformations was 1.2 % of the total live births. Distribution of malformation was predominant among males than in females (60.67 vs. 37.37 %; p