Clinical Characteristics and Outcome of Post-Infectious Glomerulonephritis in Children in Southern India: A Prospective Study

• Published in: Indian journal of pediatrics 2015-10, Vol.82 (10), p.896-903
• Main Authors: Gunasekaran, Kuralvanan, Krishnamurthy, Sriram, Mahadevan, Subramanian, Harish, B. N., Kumar, Ajith Prabhu
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - diagnosis; Acute Kidney Injury - microbiology; Adolescent; Child; Child, Preschool; Female; Glomerulonephritis - diagnosis; Glomerulonephritis - microbiology; Gynecology; Hematuria - diagnosis; Humans; India; Infant; Kidney - pathology; Male; Medicine; Medicine & Public Health; Original Article; Pediatrics; Prognosis; Prospective Studies; Proteinuria - diagnosis; Streptococcal Infections - diagnosis; Streptococcal Infections - microbiology; Streptococcus pyogenes - isolation & purification; Tertiary Healthcare
• ISSN: 0019-5456; 0973-7693
• DOI: 10.1007/s12098-015-1752-0

Objectives To evaluate the clinical characteristics, complications and outcome of post-infectious glomerulonephritis (PIGN). Methods This prospective observational study was conducted from January 2013 through July 2014 at a tertiary care hospital in south India. Post-streptococcal glomerulonephritis (PSGN) was diagnosed in the presence of: a) Hematuria and proteinuria b) Clinico-serological evidence of recent streptococcal infection [recent pyodermas or pharyngitis; positive antistreptolysin-O (ASO) titres, anti-DNAse B titres or throat swab positivity for Group A streptococcus], and c) Low serum C3 levels, with normalization on 8 wk follow up. PIGN included PSGN and other infectious etiologies. AKI was classified as per Acute Kidney Injury Network (AKIN) criteria. Clinical features, biochemical and serological investigations in the study subjects were recorded. Results Among 83 children with acute nephritic syndrome (ANS) recruited, 72 (86.7 %) had PIGN. PSGN was the most common etiology [65(90.3 %)] among the PIGN cases. Pyodermas, upper respiratory infections and varicella preceded hematuria in 58 (80.6 %), 4 (5.6 %) and 2 (2.8 %) cases respectively. Pneumonia, mumps and liver abscess caused PIGN in 7 (9.7 %) cases. Complications included AKI in 15 (20.8 %), hypertensive emergency in 14 (19.4 %), cardiac failure in 8 (11.1 %), encephalopathy in 3 (4.2 %) cases and retinopathy in 1 (1.4 %) case. Among the AKI patients, 3(20 %) were in AKI stage 3, while 1 child required hemodialysis. Twenty three cases (31.9 %) had evidence of residual renal injury at discharge. Renal biopsy showed diffuse proliferative glomerulonephritis in 4 and crescentic glomerulonephritis in one case of PIGN. At 6 mo follow up, one patient continued to have microalbuminuria. Conclusions PIGN (including PSGN) remains a significant contributor to morbidity in children with ANS. The study is notable for high incidence of hypertensive emergency and AKI, that often required intensive care management.