Thalassaemia major and infectious risk: High Mobility Group Box‐1 represents a novel diagnostic and prognostic biomarker

Summary High mobility group box ‐1 (HMGB1) represents a common causal agent for various types of diseases, including infective pathologies. This study aimed to investigate the role of HMGB1 in β‐thalassemia major (TM) by evaluating its diagnostic and prognostic role. Fifty‐one TM patients and 30 hea...

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Published in:British journal of haematology 2015-10, Vol.171 (1), p.130-136
Main Authors: Chirico, Valeria, Lacquaniti, Antonio, Piraino, Basilia, Cutrupi, Maricia, Cuppari, Caterina, Grasso, Luisa, Rigoli, Luciana, David, Antonio, Arrigo, Teresa, Salpietro, Carmelo
Format: Article
Language:English
Subjects:
Adult
beta-Thalassemia - blood
beta-Thalassemia - diagnosis
beta-Thalassemia - surgery
Biomarkers - blood
Female
hepatitis C virus infection
HMGB1
HMGB1 Protein - blood
Humans
infection
Infection - blood
Infection - diagnosis
Infection - etiology
iron overload
Male
Prognosis
Risk Factors
Splenectomy
thalassaemia
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Summary:Summary High mobility group box ‐1 (HMGB1) represents a common causal agent for various types of diseases, including infective pathologies. This study aimed to investigate the role of HMGB1 in β‐thalassemia major (TM) by evaluating its diagnostic and prognostic role. Fifty‐one TM patients and 30 healthy subjects (HS) were enrolled. Receiver operating characteristics (ROC) analysis was employed to calculate the area under the curve (AUC) for HMGB1 to determine the best cut‐off values capable of identifying infectious episodes. Adjusted risk estimates for infective events were calculated using univariate followed by multivariate Cox proportional hazard regression analysis. Serum HMGB1 levels were higher in TM patients than in HS (14·6 ± 8·7 vs. 2·08 ± 0·9 ng/ml, P 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.13530