Cell population data in neonates: differences by age group and associations with perinatal factors

Summary Introduction Cell population data (CPD) describe physical parameters of white blood cell subpopulations and are reported to be of some value in the diagnosis of sepsis in neonates. Before using the CPD for diagnosing sepsis, the baseline features of the CPD distribution in healthy neonates s...

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Bibliographic Details
Published in:International journal of laboratory hematology 2015-10, Vol.37 (5), p.606-612
Main Authors: Lee, J., Kim, S. Y., Lee, W., Han, K., Sung, I. K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Birth Weight
Cell population data
Delivery, Obstetric - methods
Female
Gestational Age
Humans
Infant, Newborn
leukocyte
Leukocyte Count - methods
Leukocyte Count - standards
Male
neonate
Pregnancy
Risk Factors
Sepsis - blood
Sepsis - diagnosis
Young Adult
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Summary:Summary Introduction Cell population data (CPD) describe physical parameters of white blood cell subpopulations and are reported to be of some value in the diagnosis of sepsis in neonates. Before using the CPD for diagnosing sepsis, the baseline features of the CPD distribution in healthy neonates should be clarified. The aim of this study was to compare the CPD distributions of healthy neonates and other age groups and to identify perinatal factors that are associated with changes in the CPD distribution of healthy neonates. Methods The CPD distribution of 69 samples from term neonates was compared with adolescents and adults. The CPD distribution of 163 samples from healthy neonates was analyzed in association with perinatal factors, including gestational age, chronologic age, birthweight, delivery mode, premature rupture of membranes, diabetes, and pregnancy‐induced hypertension. Results The CPD distribution for term neonates was significantly different from those in adolescents and adults. The mean lymphocyte volume showed a negative correlation with gestational age at birth (r = −0.305; P 
ISSN:1751-5521
1751-553X
DOI:10.1111/ijlh.12366