Hepatoprotection of D‐Galactosamine‐Induced Toxicity in Mice by Purified Fractions from Garcinia kola Seeds

: The hepatoprotective effect of a biflavonoid complex, kolaviron, and its fractions from Garcinia kola seeds, together with the possible mechanisms involved was investigated in mice intoxicated with a single dose of D‐galactosamine (GalNH2). Likewise, the ability of vitamin E to attenuate the toxic...

Full description

Saved in:
Bibliographic Details
Published in:Basic & clinical pharmacology & toxicology 2006-02, Vol.98 (2), p.135-141
Main Authors: Adaramoye, Oluwatosin A., Adeyemi, Edward O.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical and Drug Induced Liver Injury
Flavonoids - pharmacology
Galactosamine - toxicity
Garcinia kola
Garcinia kola - chemistry
Glucose-6-Phosphatase - metabolism
Glutathione - metabolism
Lipid Peroxidation
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver Diseases - metabolism
Liver Diseases - prevention & control
Male
Medical sciences
Mice
Microsomes, Liver - metabolism
Pharmacology. Drug treatments
Protective Agents - pharmacology
Seeds - chemistry
Transferases - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: The hepatoprotective effect of a biflavonoid complex, kolaviron, and its fractions from Garcinia kola seeds, together with the possible mechanisms involved was investigated in mice intoxicated with a single dose of D‐galactosamine (GalNH2). Likewise, the ability of vitamin E to attenuate the toxicity was examined. Kolaviron, was separated by thin‐layer chromatographic technique into three fractions; Fraction I, Fraction II and Fraction III with RF values of 0.48, 0.71 and 0.76, respectively. Pretreatment with kolaviron, fraction I and fraction II at a dose of 100 mg/kg for seven consecutive days before challenge with a single dose of GalNH2 (800 mg/ kg) significantly (P
ISSN:1742-7835
1742-7843
DOI:10.1111/j.1742-7843.2006.pto_256.x