A randomized trial to compare the efficacy and tolerability of sodium picosulfate-magnesium citrate solution vs. 4 L polyethylene glycol solution as a bowel preparation for colonoscopy

Purpose The purpose of this study is to compare the efficacy and acceptability of an evening-before regimens of sodium picosulfate/magnesium citrate (SPMC) and polyethylene glycol (PEG) as bowel cleansers and to explore the results of a same-day regimen of SPMC. Methods Multicenter, randomized, obse...

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Bibliographic Details
Published in:International journal of colorectal disease 2015-10, Vol.30 (10), p.1407-1416
Main Authors: Muñoz-Navas, Miguel, Calleja, José Luis, Payeras, Guillermo, Hervás, Antonio José, Abreu, Luis Esteban, Orive, Víctor, Menchén, Pedro L., Bordas, José María, Armengol, José Ramón, Carretero, Cristina, Beltrán, Vicente Pons, Alonso-Abreu, Inmaculada, Manteca, Román, Parra-Blanco, Adolfo, Carballo, Fernando, Herrerías, Juan Manuel, Badiola, Carlos
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Cathartics - administration & dosage
Cathartics - adverse effects
Citrates - administration & dosage
Citrates - adverse effects
Citric Acid - administration & dosage
Citric Acid - adverse effects
Colonoscopy
Colonoscopy - methods
Drug Administration Schedule
Female
Gastroenterology
Gastrointestinal Diseases - chemically induced
Hepatology
Humans
Internal Medicine
Magnesium citrate
Male
Medicine
Medicine & Public Health
Middle Aged
Organometallic Compounds - administration & dosage
Organometallic Compounds - adverse effects
Original Article
Patient Satisfaction
Picolines - administration & dosage
Picolines - adverse effects
Polyethylene glycol
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - adverse effects
Proctology
Surgery
Young Adult
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Summary:Purpose The purpose of this study is to compare the efficacy and acceptability of an evening-before regimens of sodium picosulfate/magnesium citrate (SPMC) and polyethylene glycol (PEG) as bowel cleansers and to explore the results of a same-day regimen of SPMC. Methods Multicenter, randomized, observer-blinded, parallel study carried out in subjects who were 18–80 years old and were undergoing diagnostic colonoscopy for the first time. The primary outcome was treatment success, which was a composite outcome defined by (1) the evaluation of the overall preparation quality as “excellent” or “good” by two blinded independent evaluators with the Fleet® Grading Scale for Bowel Cleansing and (2) a subject’s acceptability rating of “easy to take” or “tolerable.” The primary outcome was analyzed using a logistic regression with site, gender, and age group (age ≥65 years and
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-015-2307-6