Comparison of stretched-Exponential and monoexponential model diffusion-Weighted imaging in prostate cancer and normal tissues

• Published in: Journal of magnetic resonance imaging 2015-10, Vol.42 (4), p.1078-1085
• Main Authors: Liu, Xiaohang, Zhou, Liangping, Peng, Weijun, Wang, He, Zhang, Yong
• Format: Article
• Language: English
• Subjects: Aged; Algorithms; Diffusion Magnetic Resonance Imaging - methods; diffusion-weighted imaging; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Magnetic resonance imaging; Male; Middle Aged; prostate; Prostate - pathology; Prostatic Neoplasms - pathology; Reproducibility of Results; Sensitivity and Specificity; stretched-exponential model
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.24872

Background To compare stretched‐exponential and monoexponential model diffusion‐weighted imaging (DWI) in prostate cancer and normal tissues. Methods Twenty‐seven patients with prostate cancer underwent DWI exam using b‐values of 0, 500, 1000, and 2000 s/mm2. The distributed diffusion coefficients (DDC) and α values of prostate cancer and normal tissues were obtained with stretched‐exponential model and apparent diffusion coefficient (ADC) values using monoexponential model. The ADC, DDC (both in 10−3 mm2/s), and α values (range, 0–1) were compared among different prostate tissues. The ADC and DDC were also compared and correlated in each tissue, and the standardized differences between DDC and ADC were compared among different tissues. Results Data were obtained for 31 cancers, 36 normal peripheral zone (PZ) and 26 normal central gland (CG) tissues. The ADC (0.71 ± 0.12), DDC (0.60 ± 0.18), and α value (0.64 ± 0.05) of tumor were all significantly lower than those of the normal PZ (1.41 ± 0.22, 1.47 ± 0.20, and 0.85 ± 0.09) and CG (1.25 ± 0.14, 1.32 ± 0.13, and 0.82 ± 0.06) (all P