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Age Threshold for Increased Stroke Risk Among Patients With Atrial Fibrillation: A Nationwide Cohort Study From Taiwan
Recent studies from Asia have suggested that the risk of ischemic stroke for patients with atrial fibrillation (AF) with a "low-risk" congestive heart failure, hypertension, age ≥75, diabetes mellitus, prior stroke or transient ischemic attack, vascular disease, age 65 to 74, female (CHA2D...
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| Published in: | Journal of the American College of Cardiology 2015-09, Vol.66 (12), p.1339-1347 |
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| container_title | Journal of the American College of Cardiology |
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| creator | Chao, Tze-Fan Wang, Kang-Ling Liu, Chia-Jen Lin, Yenn-Jiang Chang, Shih-Lin Lo, Li-Wei Hu, Yu-Feng Tuan, Ta-Chuan Chung, Fa-Po Liao, Jo-Nan Chen, Tzeng-Ji Chiang, Chern-En Lip, Gregory Y H Chen, Shih-Ann |
| description | Recent studies from Asia have suggested that the risk of ischemic stroke for patients with atrial fibrillation (AF) with a "low-risk" congestive heart failure, hypertension, age ≥75, diabetes mellitus, prior stroke or transient ischemic attack, vascular disease, age 65 to 74, female (CHA2DS2-VASc) score of 0 (for males) or 1 (for females) might be higher than that for non-Asians.
This study hypothesized that the age threshold (65 years) used in the CHA2DS2-VASc system for initiating oral anticoagulants (OACs) might be lower in Taiwanese AF patients than in non-Asians.
We used the National Health Insurance Research Database in Taiwan to study 186,570 nonanticoagulated AF patients. There were 9,416 males with a CHA2DS2-VASc score of 0 and 6,390 females with a CHA2DS2-VASc score of 1. Their risk of ischemic stroke was analyzed with stratification on the basis of age.
The annual risks of ischemic stroke for males (score 0) and females (score 1) were 1.15% and 1.12%, respectively, and continuously increased from younger to older age groups, with an increment in stroke risk evident for patients >50 years of age. At a cutoff of 50 years, patients could be further stratified into 2 subgroups with different stroke risks (>50 years of age: 1.78%/year; vs. |
| doi_str_mv | 10.1016/j.jacc.2015.07.026 |
| format | article |
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This study hypothesized that the age threshold (65 years) used in the CHA2DS2-VASc system for initiating oral anticoagulants (OACs) might be lower in Taiwanese AF patients than in non-Asians.
We used the National Health Insurance Research Database in Taiwan to study 186,570 nonanticoagulated AF patients. There were 9,416 males with a CHA2DS2-VASc score of 0 and 6,390 females with a CHA2DS2-VASc score of 1. Their risk of ischemic stroke was analyzed with stratification on the basis of age.
The annual risks of ischemic stroke for males (score 0) and females (score 1) were 1.15% and 1.12%, respectively, and continuously increased from younger to older age groups, with an increment in stroke risk evident for patients >50 years of age. At a cutoff of 50 years, patients could be further stratified into 2 subgroups with different stroke risks (>50 years of age: 1.78%/year; vs. <50 years of age: 0.53%/year). This observation was consistent for males (1.95%/year vs. 0.46%/year, respectively) and females (1.58%/year vs. 0.64%/year, respectively) with AF. In a subgroup analysis, the annual risks of ischemic stroke for males and females with AF 50 to 54 years of age were 1.47% and 1.07%, respectively.
For Taiwanese patients 50 to 64 years of age, the annual stroke risk was 1.78%, which may exceed the threshold for OAC use for stroke prevention. The annual risk of ischemic stroke for AF patients <50 years of age was 0.53%, which was truly low-risk, and OACs could be omitted. Whether resetting the age threshold to 50 years could refine current clinical risk stratification for Asian AF patients deserves further study.</description><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2015.07.026</identifier><identifier>PMID: 26383720</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Age Factors ; Anticoagulants - therapeutic use ; Atrial Fibrillation - complications ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Risk Assessment ; Stroke - epidemiology ; Stroke - etiology ; Stroke - prevention & control ; Taiwan - epidemiology</subject><ispartof>Journal of the American College of Cardiology, 2015-09, Vol.66 (12), p.1339-1347</ispartof><rights>Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26383720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chao, Tze-Fan</creatorcontrib><creatorcontrib>Wang, Kang-Ling</creatorcontrib><creatorcontrib>Liu, Chia-Jen</creatorcontrib><creatorcontrib>Lin, Yenn-Jiang</creatorcontrib><creatorcontrib>Chang, Shih-Lin</creatorcontrib><creatorcontrib>Lo, Li-Wei</creatorcontrib><creatorcontrib>Hu, Yu-Feng</creatorcontrib><creatorcontrib>Tuan, Ta-Chuan</creatorcontrib><creatorcontrib>Chung, Fa-Po</creatorcontrib><creatorcontrib>Liao, Jo-Nan</creatorcontrib><creatorcontrib>Chen, Tzeng-Ji</creatorcontrib><creatorcontrib>Chiang, Chern-En</creatorcontrib><creatorcontrib>Lip, Gregory Y H</creatorcontrib><creatorcontrib>Chen, Shih-Ann</creatorcontrib><title>Age Threshold for Increased Stroke Risk Among Patients With Atrial Fibrillation: A Nationwide Cohort Study From Taiwan</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Recent studies from Asia have suggested that the risk of ischemic stroke for patients with atrial fibrillation (AF) with a "low-risk" congestive heart failure, hypertension, age ≥75, diabetes mellitus, prior stroke or transient ischemic attack, vascular disease, age 65 to 74, female (CHA2DS2-VASc) score of 0 (for males) or 1 (for females) might be higher than that for non-Asians.
This study hypothesized that the age threshold (65 years) used in the CHA2DS2-VASc system for initiating oral anticoagulants (OACs) might be lower in Taiwanese AF patients than in non-Asians.
We used the National Health Insurance Research Database in Taiwan to study 186,570 nonanticoagulated AF patients. There were 9,416 males with a CHA2DS2-VASc score of 0 and 6,390 females with a CHA2DS2-VASc score of 1. Their risk of ischemic stroke was analyzed with stratification on the basis of age.
The annual risks of ischemic stroke for males (score 0) and females (score 1) were 1.15% and 1.12%, respectively, and continuously increased from younger to older age groups, with an increment in stroke risk evident for patients >50 years of age. At a cutoff of 50 years, patients could be further stratified into 2 subgroups with different stroke risks (>50 years of age: 1.78%/year; vs. <50 years of age: 0.53%/year). This observation was consistent for males (1.95%/year vs. 0.46%/year, respectively) and females (1.58%/year vs. 0.64%/year, respectively) with AF. In a subgroup analysis, the annual risks of ischemic stroke for males and females with AF 50 to 54 years of age were 1.47% and 1.07%, respectively.
For Taiwanese patients 50 to 64 years of age, the annual stroke risk was 1.78%, which may exceed the threshold for OAC use for stroke prevention. The annual risk of ischemic stroke for AF patients <50 years of age was 0.53%, which was truly low-risk, and OACs could be omitted. Whether resetting the age threshold to 50 years could refine current clinical risk stratification for Asian AF patients deserves further study.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Anticoagulants - therapeutic use</subject><subject>Atrial Fibrillation - complications</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Assessment</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>Stroke - prevention & control</subject><subject>Taiwan - epidemiology</subject><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNo1UM1LwzAcDYK4Of0HPEiOXlrza9ok9VaG08FQ0YnHkqbpmq1tZtI69t9b_Di9B--Dx0PoCkgIBNjtNtxKpcKIQBISHpKInaApJIkIaJLyCTr3fksIYQLSMzSJGBWUR2SKvrKNxuvaaV_bpsSVdXjZKael1yV-653dafxq_A5nre02-EX2Rne9xx-mr3HWOyMbvDCFM00zSra7wxl--mEHU2o8t7V1_Vg0lEe8cLbFa2kOsrtAp5VsvL78wxl6X9yv54_B6vlhOc9WwT4C6AOuGBNRKVLOSDEurjiXlU5UUUYVAMQkhYpXTAgKMU8pAIlKpdQYkSyNuaQzdPPbu3f2c9C-z1vjlR7HdtoOPgcONI2pYHS0Xv9Zh6LVZb53ppXumP9_Rb8B9TtqUA</recordid><startdate>20150922</startdate><enddate>20150922</enddate><creator>Chao, Tze-Fan</creator><creator>Wang, Kang-Ling</creator><creator>Liu, Chia-Jen</creator><creator>Lin, Yenn-Jiang</creator><creator>Chang, Shih-Lin</creator><creator>Lo, Li-Wei</creator><creator>Hu, Yu-Feng</creator><creator>Tuan, Ta-Chuan</creator><creator>Chung, Fa-Po</creator><creator>Liao, Jo-Nan</creator><creator>Chen, Tzeng-Ji</creator><creator>Chiang, Chern-En</creator><creator>Lip, Gregory Y H</creator><creator>Chen, Shih-Ann</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20150922</creationdate><title>Age Threshold for Increased Stroke Risk Among Patients With Atrial Fibrillation: A Nationwide Cohort Study From Taiwan</title><author>Chao, Tze-Fan ; Wang, Kang-Ling ; Liu, Chia-Jen ; Lin, Yenn-Jiang ; Chang, Shih-Lin ; Lo, Li-Wei ; Hu, Yu-Feng ; Tuan, Ta-Chuan ; Chung, Fa-Po ; Liao, Jo-Nan ; Chen, Tzeng-Ji ; Chiang, Chern-En ; Lip, Gregory Y H ; Chen, Shih-Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-7c6682d89760b837f77afe5cbd2f1114091f7f6883147931102dccc82da6947a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Anticoagulants - therapeutic use</topic><topic>Atrial Fibrillation - complications</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Assessment</topic><topic>Stroke - epidemiology</topic><topic>Stroke - etiology</topic><topic>Stroke - prevention & control</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chao, Tze-Fan</creatorcontrib><creatorcontrib>Wang, Kang-Ling</creatorcontrib><creatorcontrib>Liu, Chia-Jen</creatorcontrib><creatorcontrib>Lin, Yenn-Jiang</creatorcontrib><creatorcontrib>Chang, Shih-Lin</creatorcontrib><creatorcontrib>Lo, Li-Wei</creatorcontrib><creatorcontrib>Hu, Yu-Feng</creatorcontrib><creatorcontrib>Tuan, Ta-Chuan</creatorcontrib><creatorcontrib>Chung, Fa-Po</creatorcontrib><creatorcontrib>Liao, Jo-Nan</creatorcontrib><creatorcontrib>Chen, Tzeng-Ji</creatorcontrib><creatorcontrib>Chiang, Chern-En</creatorcontrib><creatorcontrib>Lip, Gregory Y H</creatorcontrib><creatorcontrib>Chen, Shih-Ann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chao, Tze-Fan</au><au>Wang, Kang-Ling</au><au>Liu, Chia-Jen</au><au>Lin, Yenn-Jiang</au><au>Chang, Shih-Lin</au><au>Lo, Li-Wei</au><au>Hu, Yu-Feng</au><au>Tuan, Ta-Chuan</au><au>Chung, Fa-Po</au><au>Liao, Jo-Nan</au><au>Chen, Tzeng-Ji</au><au>Chiang, Chern-En</au><au>Lip, Gregory Y H</au><au>Chen, Shih-Ann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age Threshold for Increased Stroke Risk Among Patients With Atrial Fibrillation: A Nationwide Cohort Study From Taiwan</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2015-09-22</date><risdate>2015</risdate><volume>66</volume><issue>12</issue><spage>1339</spage><epage>1347</epage><pages>1339-1347</pages><eissn>1558-3597</eissn><abstract>Recent studies from Asia have suggested that the risk of ischemic stroke for patients with atrial fibrillation (AF) with a "low-risk" congestive heart failure, hypertension, age ≥75, diabetes mellitus, prior stroke or transient ischemic attack, vascular disease, age 65 to 74, female (CHA2DS2-VASc) score of 0 (for males) or 1 (for females) might be higher than that for non-Asians.
This study hypothesized that the age threshold (65 years) used in the CHA2DS2-VASc system for initiating oral anticoagulants (OACs) might be lower in Taiwanese AF patients than in non-Asians.
We used the National Health Insurance Research Database in Taiwan to study 186,570 nonanticoagulated AF patients. There were 9,416 males with a CHA2DS2-VASc score of 0 and 6,390 females with a CHA2DS2-VASc score of 1. Their risk of ischemic stroke was analyzed with stratification on the basis of age.
The annual risks of ischemic stroke for males (score 0) and females (score 1) were 1.15% and 1.12%, respectively, and continuously increased from younger to older age groups, with an increment in stroke risk evident for patients >50 years of age. At a cutoff of 50 years, patients could be further stratified into 2 subgroups with different stroke risks (>50 years of age: 1.78%/year; vs. <50 years of age: 0.53%/year). This observation was consistent for males (1.95%/year vs. 0.46%/year, respectively) and females (1.58%/year vs. 0.64%/year, respectively) with AF. In a subgroup analysis, the annual risks of ischemic stroke for males and females with AF 50 to 54 years of age were 1.47% and 1.07%, respectively.
For Taiwanese patients 50 to 64 years of age, the annual stroke risk was 1.78%, which may exceed the threshold for OAC use for stroke prevention. The annual risk of ischemic stroke for AF patients <50 years of age was 0.53%, which was truly low-risk, and OACs could be omitted. Whether resetting the age threshold to 50 years could refine current clinical risk stratification for Asian AF patients deserves further study.</abstract><cop>United States</cop><pmid>26383720</pmid><doi>10.1016/j.jacc.2015.07.026</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 2015-09, Vol.66 (12), p.1339-1347 |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Adult Age Factors Anticoagulants - therapeutic use Atrial Fibrillation - complications Cohort Studies Female Humans Male Middle Aged Risk Assessment Stroke - epidemiology Stroke - etiology Stroke - prevention & control Taiwan - epidemiology |
| title | Age Threshold for Increased Stroke Risk Among Patients With Atrial Fibrillation: A Nationwide Cohort Study From Taiwan |
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