Concurrent deletion of 16q23 and PTEN is an independent prognostic feature in prostate cancer

The deletion of 16q23‐q24 belongs to the most frequent chromosomal changes in prostate cancer, but the clinical consequences of this alteration have not been studied in detail. We performed fluorescence in situ hybridization analysis using a 16q23 probe in more than 7,400 prostate cancers with clini...

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Bibliographic Details
Published in:International journal of cancer 2015-11, Vol.137 (10), p.2354-2363
Main Authors: Kluth, Martina, Runte, Frederic, Barow, Philipp, Omari, Jazan, Abdelaziz, Zaid M., Paustian, Lisa, Steurer, Stefan, Christina Tsourlakis, Maria, Fisch, Margit, Graefen, Markus, Tennstedt, Pierre, Huland, Hartwig, Michl, Uwe, Minner, Sarah, Sauter, Guido, Simon, Ronald, Adam, Meike, Schlomm, Thorsten
Format: Article
Language:English
Subjects:
16q deletion
Adult
Aged
biological endpoints
Cancer
Cell proliferation
Chromosome deletion
Chromosomes, Human, Pair 16 - genetics
Disease Progression
Fluorescence in situ hybridization
Humans
Hybridization analysis
In Situ Hybridization, Fluorescence - methods
Lymph nodes
Male
Medical prognosis
Medical research
Metastases
Middle Aged
Neoplasm Grading
Prostate cancer
prostate cancer prognosis
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
PTEN deletion
PTEN Phosphohydrolase - genetics
PTEN protein
Risk assessment
Sequence Deletion
Tissue Array Analysis - methods
tissue microarray
Tumors
WWOX
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Summary:The deletion of 16q23‐q24 belongs to the most frequent chromosomal changes in prostate cancer, but the clinical consequences of this alteration have not been studied in detail. We performed fluorescence in situ hybridization analysis using a 16q23 probe in more than 7,400 prostate cancers with clinical follow‐up data assembled in a tissue microarray format. Chromosome 16q deletion was found in 21% of cancers, and was linked to advanced tumor stage, high Gleason grade, accelerated cell proliferation, the presence of lymph node metastases (p 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.29613