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Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice
Pregnant women who are obese or have gestational diabetes mellitus have elevated leptin levels and their children have an increased risk for child and adult obesity. The goals of this study were to determine whether offspring weights are altered by maternal hyperleptinemia, and whether this occurs v...
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Published in: | Endocrinology (Philadelphia) 2015-10, Vol.156 (10), p.3777-3790 |
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description | Pregnant women who are obese or have gestational diabetes mellitus have elevated leptin levels and their children have an increased risk for child and adult obesity. The goals of this study were to determine whether offspring weights are altered by maternal hyperleptinemia, and whether this occurs via behavioral changes that influence energy balance. We used 2 hyperleptinemic mouse models. The first was females heterozygous for a leptin receptor mutation (DB/+), which were severely hyperleptinemic, and that were compared with wild-type females. The second model was wild-type females infused with leptin (LEP), which were moderately hyperleptinemic, and were compared with wild-type females infused with saline (SAL). Total food consumption, food preference, locomotor activity, coordinated motor skills, and anxiety-like behaviors were assessed in wild-type offspring from each maternal group at 3 postnatal ages: 4–6, 11–13, and 19–21 weeks. Half the offspring from each group were then placed on a high-fat diet, and behaviors were reassessed. Adult offspring from both groups of hyperleptinemic dams weighed less than their respective controls beginning at 23 weeks of age, independent of diet or sex. Weight differences were not explained by food consumption or preference, because female offspring from hyperleptinemic dams tended to consume more food and had reduced preference for palatable, high-fat and sugar, food compared with controls. Offspring from DB/+ dams were more active than offspring of controls, as were female offspring of LEP dams. Maternal hyperleptinemia during pregnancy did not predispose offspring to obesity, and in fact, reduced weight gain. |
doi_str_mv | 10.1210/en.2015-1247 |
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The goals of this study were to determine whether offspring weights are altered by maternal hyperleptinemia, and whether this occurs via behavioral changes that influence energy balance. We used 2 hyperleptinemic mouse models. The first was females heterozygous for a leptin receptor mutation (DB/+), which were severely hyperleptinemic, and that were compared with wild-type females. The second model was wild-type females infused with leptin (LEP), which were moderately hyperleptinemic, and were compared with wild-type females infused with saline (SAL). Total food consumption, food preference, locomotor activity, coordinated motor skills, and anxiety-like behaviors were assessed in wild-type offspring from each maternal group at 3 postnatal ages: 4–6, 11–13, and 19–21 weeks. Half the offspring from each group were then placed on a high-fat diet, and behaviors were reassessed. Adult offspring from both groups of hyperleptinemic dams weighed less than their respective controls beginning at 23 weeks of age, independent of diet or sex. Weight differences were not explained by food consumption or preference, because female offspring from hyperleptinemic dams tended to consume more food and had reduced preference for palatable, high-fat and sugar, food compared with controls. Offspring from DB/+ dams were more active than offspring of controls, as were female offspring of LEP dams. Maternal hyperleptinemia during pregnancy did not predispose offspring to obesity, and in fact, reduced weight gain.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2015-1247</identifier><identifier>PMID: 26196541</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Animal models ; Animals ; Anxiety ; Body Weight - drug effects ; Body Weight - genetics ; Body Weight - physiology ; Body weight gain ; Dams ; Diabetes mellitus ; Diet ; Diet, High-Fat ; Eating - drug effects ; Eating - genetics ; Energy balance ; Exploratory Behavior - drug effects ; Female ; Females ; Food ; Food consumption ; Food preferences ; Gene Expression ; Group dynamics ; High fat diet ; Leptin - blood ; Leptin - pharmacology ; Locomotor activity ; Male ; Maternal behavior ; Metabolic Diseases - blood ; Metabolic Diseases - physiopathology ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity - drug effects ; Motor Activity - genetics ; Motor Activity - physiology ; Motor skill ; Mutation ; Obesity ; Obesity - etiology ; Obesity - genetics ; Obesity - physiopathology ; Offspring ; Pregnancy ; Pregnancy complications ; Pregnancy Complications - blood ; Pregnancy Complications - physiopathology ; Receptors, Leptin - genetics ; Receptors, Leptin - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Time Factors</subject><ispartof>Endocrinology (Philadelphia), 2015-10, Vol.156 (10), p.3777-3790</ispartof><rights>Copyright © 2015 by the Endocrine Society</rights><rights>Copyright © 2015 by the Endocrine Society 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-59a3f5485db923fcc1618dbe39ab4a26e480b18c8e373e601b5646484b97710b3</citedby><cites>FETCH-LOGICAL-c433t-59a3f5485db923fcc1618dbe39ab4a26e480b18c8e373e601b5646484b97710b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26196541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pollock, Kelly E</creatorcontrib><creatorcontrib>Stevens, Damaiyah</creatorcontrib><creatorcontrib>Pennington, Kathleen A</creatorcontrib><creatorcontrib>Thaisrivongs, Rose</creatorcontrib><creatorcontrib>Kaiser, Jennifer</creatorcontrib><creatorcontrib>Ellersieck, Mark R</creatorcontrib><creatorcontrib>Miller, Dennis K</creatorcontrib><creatorcontrib>Schulz, Laura Clamon</creatorcontrib><title>Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Pregnant women who are obese or have gestational diabetes mellitus have elevated leptin levels and their children have an increased risk for child and adult obesity. The goals of this study were to determine whether offspring weights are altered by maternal hyperleptinemia, and whether this occurs via behavioral changes that influence energy balance. We used 2 hyperleptinemic mouse models. The first was females heterozygous for a leptin receptor mutation (DB/+), which were severely hyperleptinemic, and that were compared with wild-type females. The second model was wild-type females infused with leptin (LEP), which were moderately hyperleptinemic, and were compared with wild-type females infused with saline (SAL). Total food consumption, food preference, locomotor activity, coordinated motor skills, and anxiety-like behaviors were assessed in wild-type offspring from each maternal group at 3 postnatal ages: 4–6, 11–13, and 19–21 weeks. Half the offspring from each group were then placed on a high-fat diet, and behaviors were reassessed. Adult offspring from both groups of hyperleptinemic dams weighed less than their respective controls beginning at 23 weeks of age, independent of diet or sex. Weight differences were not explained by food consumption or preference, because female offspring from hyperleptinemic dams tended to consume more food and had reduced preference for palatable, high-fat and sugar, food compared with controls. Offspring from DB/+ dams were more active than offspring of controls, as were female offspring of LEP dams. Maternal hyperleptinemia during pregnancy did not predispose offspring to obesity, and in fact, reduced weight gain.</description><subject>Animal models</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - genetics</subject><subject>Body Weight - physiology</subject><subject>Body weight gain</subject><subject>Dams</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Eating - drug effects</subject><subject>Eating - genetics</subject><subject>Energy balance</subject><subject>Exploratory Behavior - drug effects</subject><subject>Female</subject><subject>Females</subject><subject>Food</subject><subject>Food consumption</subject><subject>Food preferences</subject><subject>Gene Expression</subject><subject>Group dynamics</subject><subject>High fat diet</subject><subject>Leptin - blood</subject><subject>Leptin - pharmacology</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Maternal behavior</subject><subject>Metabolic Diseases - blood</subject><subject>Metabolic Diseases - physiopathology</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - genetics</subject><subject>Motor Activity - physiology</subject><subject>Motor skill</subject><subject>Mutation</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - genetics</subject><subject>Obesity - physiopathology</subject><subject>Offspring</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnancy Complications - blood</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Receptors, Leptin - genetics</subject><subject>Receptors, Leptin - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Time Factors</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp10c1u1DAUBWALgei0sGONLLFoF6T4xk6cLEct0JEGlQWoy8hxbqauEjvYDtK8Ak-Nhww_QrCyLH0-ur6HkBfALiEH9gbtZc6gyCAX8hFZQS2KTIJkj8mKMeCZzHN5Qk5DeEhXIQR_Sk7yEuqyELAi3272E_oBp2gsjkbR69kbu6MfPe6ssnpPr1F7VAEDXXfzEOkdmt19pK6nt30fph9a2Y5uEgjBaaMidvTOxHu6scvT7g-6ddqNLjpP1zqarybuqbH0g9H4jDzp1RDw-fE8I5_fvf10dZNtb99vrtbbTAvOY1bUiveFqIqurXPeaw0lVF2LvFatUHmJomItVLpCLjmWDNqiFKWoRFtLCazlZ-RiyZ28-zJjiM1ogsZhUBbdHBqQwOu0J8kTffUXfXCzt2m6hgNnkomqLJN6vSjtXQge-yZ9dVR-3wBrDh01aJtDR82ho8RfHkPndsTuF_5ZSgLnC3Dz9L-o7BjFF4m2czrtFyePIfye8p8DfAfgX6mp</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Pollock, Kelly E</creator><creator>Stevens, Damaiyah</creator><creator>Pennington, Kathleen A</creator><creator>Thaisrivongs, Rose</creator><creator>Kaiser, Jennifer</creator><creator>Ellersieck, Mark R</creator><creator>Miller, Dennis K</creator><creator>Schulz, Laura Clamon</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice</title><author>Pollock, Kelly E ; Stevens, Damaiyah ; Pennington, Kathleen A ; Thaisrivongs, Rose ; Kaiser, Jennifer ; Ellersieck, Mark R ; Miller, Dennis K ; Schulz, Laura Clamon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-59a3f5485db923fcc1618dbe39ab4a26e480b18c8e373e601b5646484b97710b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - genetics</topic><topic>Body Weight - physiology</topic><topic>Body weight gain</topic><topic>Dams</topic><topic>Diabetes mellitus</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Eating - drug effects</topic><topic>Eating - genetics</topic><topic>Energy balance</topic><topic>Exploratory Behavior - drug effects</topic><topic>Female</topic><topic>Females</topic><topic>Food</topic><topic>Food consumption</topic><topic>Food preferences</topic><topic>Gene Expression</topic><topic>Group dynamics</topic><topic>High fat diet</topic><topic>Leptin - blood</topic><topic>Leptin - pharmacology</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Maternal behavior</topic><topic>Metabolic Diseases - blood</topic><topic>Metabolic Diseases - physiopathology</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - genetics</topic><topic>Motor Activity - physiology</topic><topic>Motor skill</topic><topic>Mutation</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - genetics</topic><topic>Obesity - physiopathology</topic><topic>Offspring</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnancy Complications - blood</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Receptors, Leptin - genetics</topic><topic>Receptors, Leptin - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pollock, Kelly E</creatorcontrib><creatorcontrib>Stevens, Damaiyah</creatorcontrib><creatorcontrib>Pennington, Kathleen A</creatorcontrib><creatorcontrib>Thaisrivongs, Rose</creatorcontrib><creatorcontrib>Kaiser, Jennifer</creatorcontrib><creatorcontrib>Ellersieck, Mark R</creatorcontrib><creatorcontrib>Miller, Dennis K</creatorcontrib><creatorcontrib>Schulz, Laura Clamon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pollock, Kelly E</au><au>Stevens, Damaiyah</au><au>Pennington, Kathleen A</au><au>Thaisrivongs, Rose</au><au>Kaiser, Jennifer</au><au>Ellersieck, Mark R</au><au>Miller, Dennis K</au><au>Schulz, Laura Clamon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2015-10</date><risdate>2015</risdate><volume>156</volume><issue>10</issue><spage>3777</spage><epage>3790</epage><pages>3777-3790</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><abstract>Pregnant women who are obese or have gestational diabetes mellitus have elevated leptin levels and their children have an increased risk for child and adult obesity. The goals of this study were to determine whether offspring weights are altered by maternal hyperleptinemia, and whether this occurs via behavioral changes that influence energy balance. We used 2 hyperleptinemic mouse models. The first was females heterozygous for a leptin receptor mutation (DB/+), which were severely hyperleptinemic, and that were compared with wild-type females. The second model was wild-type females infused with leptin (LEP), which were moderately hyperleptinemic, and were compared with wild-type females infused with saline (SAL). Total food consumption, food preference, locomotor activity, coordinated motor skills, and anxiety-like behaviors were assessed in wild-type offspring from each maternal group at 3 postnatal ages: 4–6, 11–13, and 19–21 weeks. Half the offspring from each group were then placed on a high-fat diet, and behaviors were reassessed. Adult offspring from both groups of hyperleptinemic dams weighed less than their respective controls beginning at 23 weeks of age, independent of diet or sex. Weight differences were not explained by food consumption or preference, because female offspring from hyperleptinemic dams tended to consume more food and had reduced preference for palatable, high-fat and sugar, food compared with controls. Offspring from DB/+ dams were more active than offspring of controls, as were female offspring of LEP dams. Maternal hyperleptinemia during pregnancy did not predispose offspring to obesity, and in fact, reduced weight gain.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>26196541</pmid><doi>10.1210/en.2015-1247</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animal models Animals Anxiety Body Weight - drug effects Body Weight - genetics Body Weight - physiology Body weight gain Dams Diabetes mellitus Diet Diet, High-Fat Eating - drug effects Eating - genetics Energy balance Exploratory Behavior - drug effects Female Females Food Food consumption Food preferences Gene Expression Group dynamics High fat diet Leptin - blood Leptin - pharmacology Locomotor activity Male Maternal behavior Metabolic Diseases - blood Metabolic Diseases - physiopathology Mice, Inbred C57BL Mice, Knockout Motor Activity - drug effects Motor Activity - genetics Motor Activity - physiology Motor skill Mutation Obesity Obesity - etiology Obesity - genetics Obesity - physiopathology Offspring Pregnancy Pregnancy complications Pregnancy Complications - blood Pregnancy Complications - physiopathology Receptors, Leptin - genetics Receptors, Leptin - metabolism Reverse Transcriptase Polymerase Chain Reaction Time Factors |
title | Hyperleptinemia During Pregnancy Decreases Adult Weight of Offspring and Is Associated With Increased Offspring Locomotor Activity in Mice |
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