Hemodilution Combined With Hypercapnia Impairs Cerebral Autoregulation During Normothermic Cardiopulmonary Bypass

Objective To investigate the influence of hemodilution and arterial pCO2 on cerebral autoregulation and cerebral vascular CO2 reactivity. Design Prospective interventional study. Setting University hospital-based single-center study. Participants Forty adult patients undergoing elective cardiac surg...

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Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 2015-10, Vol.29 (5), p.1194-1199
Main Authors: Ševerdija, Ervin E., EKP, Vranken, Nousjka P.A., BASc, Simons, Antoine P., EKP, PhD, Gommer, Erik D., MSc, PhD, Heijmans, John H., MD, PhD, Maessen, Jos G., MD, PhD, Weerwind, Patrick W., CCP, PhD
Format: Article
Language:English
Subjects:
Anesthesia & Perioperative Care
Carbon Dioxide - blood
Cardiopulmonary Bypass
cerebral autoregulation
cerebral carbon dioxide reactivity
Cerebrovascular Circulation - physiology
Critical Care
hemodilution
Hemodilution - adverse effects
Homeostasis - physiology
Humans
Hypercapnia - physiopathology
Male
Middle Aged
Oximetry
Prospective Studies
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Summary:Objective To investigate the influence of hemodilution and arterial pCO2 on cerebral autoregulation and cerebral vascular CO2 reactivity. Design Prospective interventional study. Setting University hospital-based single-center study. Participants Forty adult patients undergoing elective cardiac surgery using normothermic cardiopulmonary bypass. Interventions Blood pressure variations induced by 6/minute metronome-triggered breathing (baseline) and cyclic 6/min changes of indexed pump flow at 3 levels of arterial pCO2. Measurements and Main Results Based on median hematocrit on bypass, patients were assigned to either a group of a hematocrit≥28% or
ISSN:1053-0770
1532-8422
DOI:10.1053/j.jvca.2015.03.022