Collagen type I coating stimulates bone regeneration and osteointegration of titanium implants in the osteopenic rat

Purpose To investigate the effects of titanium implants functionalised with collagen type I (TiColl) on bone regeneration and osteointegration in a healthy and osteopenic rat animal model. Method TiColl screws were implanted into the femoral condyles of healthy and osteopenic rats and compared with...

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Bibliographic Details
Published in:International orthopaedics 2015-10, Vol.39 (10), p.2041-2052
Main Authors: Sartori, Maria, Giavaresi, Gianluca, Parrilli, Annapaola, Ferrari, Andrea, Aldini, Nicolò Nicoli, Morra, Marco, Cassinelli, Clara, Bollati, Daniele, Fini, Milena
Format: Article
Language:English
Subjects:
Animals
Bone Diseases, Metabolic - surgery
Bone Regeneration - drug effects
Bone Regeneration - physiology
Bone Screws
Coated Materials, Biocompatible
Collagen Type I - pharmacology
Disease Models, Animal
Female
Femur - drug effects
Femur - physiopathology
Femur - surgery
Humans
Medicine
Medicine & Public Health
Original Paper
Orthopedics
Osseointegration - drug effects
Osseointegration - physiology
Prosthesis Design
Rats
Rats, Sprague-Dawley
Titanium
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Summary:Purpose To investigate the effects of titanium implants functionalised with collagen type I (TiColl) on bone regeneration and osteointegration in a healthy and osteopenic rat animal model. Method TiColl screws were implanted into the femoral condyles of healthy and osteopenic rats and compared with acid-etched titanium (Ti) screws. The osteointegration process was evaluated by a complementary approach combining microtomographic, histological, histomorphometric and biomechanical investigations at four and 12 weeks. Results The TiColl screw also ensured a greater mechanical stability; the push-out values for TiColl screws increased from four to 12 weeks (+28 %). The energy necessary to detach the bone from the screw was significantly higher for TiColl-functionalised screws in comparison to Ti screws (+23 %) at 12 weeks. Histomorphometric investigation revealed that total bone-to-implant contact was higher in TiColl screws in comparison to Ti screws ( P  
ISSN:0341-2695
1432-5195
DOI:10.1007/s00264-015-2926-0