Programmed cell removal biomarkers calreticulin and CD47 implicated in oral lichen planus

Objectives To investigate the expression of the programmed cell removal markers, calreticulin (CRT) and CD47, known to be involved in various autoimmune diseases, in patients with oral lichen planus (OLP), and to investigate the association with clinical behavior. Materials and methods Biopsies of 7...

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Bibliographic Details
Published in:Oral diseases 2015-10, Vol.21 (7), p.894-898
Main Authors: Allon, I, Vered, H, Hirshberg, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers
Biomarkers - analysis
calreticulin
Calreticulin - analysis
CD47
CD47 Antigen - analysis
Dentistry
Epithelium - chemistry
Female
Humans
Lichen Planus, Oral - metabolism
Lichen Planus, Oral - pathology
Male
Middle Aged
Mouth Mucosa - chemistry
Oral diseases
oral lichen planus
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Summary:Objectives To investigate the expression of the programmed cell removal markers, calreticulin (CRT) and CD47, known to be involved in various autoimmune diseases, in patients with oral lichen planus (OLP), and to investigate the association with clinical behavior. Materials and methods Biopsies of 78 patients with OLP were included. The clinical data were collected from patients' charts. The expression of CRT and CD47 was immunomorphometrically analyzed in the epithelial (CRTep, CD47ep) and inflammatory cells (CRTinf, CD47inf), and the results were correlated with the clinical presentation. Results The epithelial and inflammatory cells expressed CRT (2.83 ± 6.62 and 5.13 ± 3.72) and CD47 (7.92 ± 4.6 and 10.7 ± 7.16). The expressions of CD47ep and CD47inf were associated (R = 0.64, P 
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12361