Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients

Objectives We investigated whether systemic lupus erythematosus (SLE) patients could be distinguished based on the time of disease onset and, if so, whether the groups differed in their clinical and laboratory features in ethnically homogeneous Korean patients. Methods We enrolled 201 SLE patients w...

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Bibliographic Details
Published in:Lupus 2015-10, Vol.24 (12), p.1342-1349
Main Authors: Choi, J H, Park, D J, Kang, J H, Yim, Y R, Lee, K E, Lee, J W, Wen, L, Kim, T J, Park, Y W, Lee, J K, Lee, S S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Age of Onset
Arthritis
Autoantibodies - blood
Autoimmune diseases
Child
Disease
Ethnicity
Female
Hospitals
Humans
Internal medicine
Laboratories
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - epidemiology
Male
Middle Aged
Nervous system
Patients
Republic of Korea - epidemiology
Rheumatology
Serology
Severity of Illness Index
Sjogren's Syndrome - epidemiology
Sociodemographics
Young Adult
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Summary:Objectives We investigated whether systemic lupus erythematosus (SLE) patients could be distinguished based on the time of disease onset and, if so, whether the groups differed in their clinical and laboratory features in ethnically homogeneous Korean patients. Methods We enrolled 201 SLE patients with available clinical data at the time of onset of SLE from the lupus cohort at Chonnam National University Hospital. Sociodemographic, clinical, and laboratory data, including autoantibodies, and concomitant diseases were found at the time of diagnosis of SLE by reviewing patient charts. We divided SLE patients according to age at SLE diagnosis into three groups: juvenile-onset SLE (JSLE, diagnosed at ≤ 18 years), adult-onset SLE (ASLE, diagnosed at 19–50 years), and late-onset SLE (LSLE, diagnosed at >50 years), and compared baseline demographic, clinical, and relevant laboratory findings. Results Of the 201 patients, 27 (14.4%), 149 (74.1%), and 25 (12.4%) were JSLE, ASLE, and LSLE patients, respectively. Fever, oral ulcers, nephritis, anemia, and thrombocytopenia were more common in JSLE patients than ASLE or LSLE patients (p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203315591024