Loading…
Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients
Objectives We investigated whether systemic lupus erythematosus (SLE) patients could be distinguished based on the time of disease onset and, if so, whether the groups differed in their clinical and laboratory features in ethnically homogeneous Korean patients. Methods We enrolled 201 SLE patients w...
Saved in:
| Published in: | Lupus 2015-10, Vol.24 (12), p.1342-1349 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c431t-c4931710f89d5c205e03e5bf0e0fab31fda39753e657b00820dec0b250947dd63 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c431t-c4931710f89d5c205e03e5bf0e0fab31fda39753e657b00820dec0b250947dd63 |
| container_end_page | 1349 |
| container_issue | 12 |
| container_start_page | 1342 |
| container_title | Lupus |
| container_volume | 24 |
| creator | Choi, J H Park, D J Kang, J H Yim, Y R Lee, K E Lee, J W Wen, L Kim, T J Park, Y W Lee, J K Lee, S S |
| description | Objectives
We investigated whether systemic lupus erythematosus (SLE) patients could be distinguished based on the time of disease onset and, if so, whether the groups differed in their clinical and laboratory features in ethnically homogeneous Korean patients.
Methods
We enrolled 201 SLE patients with available clinical data at the time of onset of SLE from the lupus cohort at Chonnam National University Hospital. Sociodemographic, clinical, and laboratory data, including autoantibodies, and concomitant diseases were found at the time of diagnosis of SLE by reviewing patient charts. We divided SLE patients according to age at SLE diagnosis into three groups: juvenile-onset SLE (JSLE, diagnosed at ≤ 18 years), adult-onset SLE (ASLE, diagnosed at 19–50 years), and late-onset SLE (LSLE, diagnosed at >50 years), and compared baseline demographic, clinical, and relevant laboratory findings.
Results
Of the 201 patients, 27 (14.4%), 149 (74.1%), and 25 (12.4%) were JSLE, ASLE, and LSLE patients, respectively. Fever, oral ulcers, nephritis, anemia, and thrombocytopenia were more common in JSLE patients than ASLE or LSLE patients (p |
| doi_str_mv | 10.1177/0961203315591024 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1713947209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203315591024</sage_id><sourcerecordid>3816138781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-c4931710f89d5c205e03e5bf0e0fab31fda39753e657b00820dec0b250947dd63</originalsourceid><addsrcrecordid>eNp1kU-LFDEQxYMo7rh69yQBLx5srSST7s5RBv_hghc9N-lOZcyQTtokLcxX8FObdlaRBS9VVOr3XgoeIU8ZvGKs616DahkHIZiUigHf3yM7tu-6pr7z-2S3rZttf0Ue5XwCAMFU-5Bc8Rb6KpE78vMQ50Unl2Og0dLJu-Am7akOhmZM0cfj79k4azFhmDBTPcdwpKf1BwbnsXlJtVl92XoVeV2wiSFjofmcC85uon5d1kwxncs3nHWJuU4u0E8xoQ500cVhKPkxeWC1z_jktl-Tr-_efjl8aG4-v_94eHPTTHvBSq1KsI6B7ZWREweJIFCOFhCsHgWzRgvVSYGt7EaAnoPBCUYuQe07Y1pxTV5cfJcUv6-YyzC7PKH3OmBc81DNRUU5qIo-v4Oe4ppCvW6jZK94L3ml4EJNKeac0A5LcrNO54HBsOU03M2pSp7dGq_jjOav4E8wFWguQNZH_OfX_xn-As8bm1c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1715892852</pqid></control><display><type>article</type><title>Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients</title><source>Sage Journals Online</source><creator>Choi, J H ; Park, D J ; Kang, J H ; Yim, Y R ; Lee, K E ; Lee, J W ; Wen, L ; Kim, T J ; Park, Y W ; Lee, J K ; Lee, S S</creator><creatorcontrib>Choi, J H ; Park, D J ; Kang, J H ; Yim, Y R ; Lee, K E ; Lee, J W ; Wen, L ; Kim, T J ; Park, Y W ; Lee, J K ; Lee, S S</creatorcontrib><description><![CDATA[Objectives
We investigated whether systemic lupus erythematosus (SLE) patients could be distinguished based on the time of disease onset and, if so, whether the groups differed in their clinical and laboratory features in ethnically homogeneous Korean patients.
Methods
We enrolled 201 SLE patients with available clinical data at the time of onset of SLE from the lupus cohort at Chonnam National University Hospital. Sociodemographic, clinical, and laboratory data, including autoantibodies, and concomitant diseases were found at the time of diagnosis of SLE by reviewing patient charts. We divided SLE patients according to age at SLE diagnosis into three groups: juvenile-onset SLE (JSLE, diagnosed at ≤ 18 years), adult-onset SLE (ASLE, diagnosed at 19–50 years), and late-onset SLE (LSLE, diagnosed at >50 years), and compared baseline demographic, clinical, and relevant laboratory findings.
Results
Of the 201 patients, 27 (14.4%), 149 (74.1%), and 25 (12.4%) were JSLE, ASLE, and LSLE patients, respectively. Fever, oral ulcers, nephritis, anemia, and thrombocytopenia were more common in JSLE patients than ASLE or LSLE patients (p < 0.05, < 0.05, 0.001, < 0.05, and < 0.05, respectively). However, Sjögren’s syndrome was more frequent in LSLE patients than JSLE or ASLE patients (p < 0.05). Disease activity was significantly higher in JSLE patients than in ASLE or LSLE patients (p < 0.001). Anti-dsDNA and anti-nucleosome antibodies were found more frequently in JSLE patients and less frequently in LSLE patients (p < 0.05 and 0.005, respectively) and decreased complement levels were more common in JSLE patients and less common in LSLE patients (p < 0.001, 0.001, and < 0.05, respectively).
Conclusions
Our results indicate that SLE patients present with different clinical and serological manifestations according to age at disease onset. JSLE patients have more severe disease activity and more frequent renal involvement and LSLE patients have milder disease activity, more commonly accompanied by Sjögren’s syndrome, at disease onset.]]></description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203315591024</identifier><identifier>PMID: 26085595</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Age ; Age Factors ; Age of Onset ; Arthritis ; Autoantibodies - blood ; Autoimmune diseases ; Child ; Disease ; Ethnicity ; Female ; Hospitals ; Humans ; Internal medicine ; Laboratories ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - epidemiology ; Male ; Middle Aged ; Nervous system ; Patients ; Republic of Korea - epidemiology ; Rheumatology ; Serology ; Severity of Illness Index ; Sjogren's Syndrome - epidemiology ; Sociodemographics ; Young Adult</subject><ispartof>Lupus, 2015-10, Vol.24 (12), p.1342-1349</ispartof><rights>The Author(s) 2015</rights><rights>The Author(s) 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-c4931710f89d5c205e03e5bf0e0fab31fda39753e657b00820dec0b250947dd63</citedby><cites>FETCH-LOGICAL-c431t-c4931710f89d5c205e03e5bf0e0fab31fda39753e657b00820dec0b250947dd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79236</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26085595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, J H</creatorcontrib><creatorcontrib>Park, D J</creatorcontrib><creatorcontrib>Kang, J H</creatorcontrib><creatorcontrib>Yim, Y R</creatorcontrib><creatorcontrib>Lee, K E</creatorcontrib><creatorcontrib>Lee, J W</creatorcontrib><creatorcontrib>Wen, L</creatorcontrib><creatorcontrib>Kim, T J</creatorcontrib><creatorcontrib>Park, Y W</creatorcontrib><creatorcontrib>Lee, J K</creatorcontrib><creatorcontrib>Lee, S S</creatorcontrib><title>Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients</title><title>Lupus</title><addtitle>Lupus</addtitle><description><![CDATA[Objectives
We investigated whether systemic lupus erythematosus (SLE) patients could be distinguished based on the time of disease onset and, if so, whether the groups differed in their clinical and laboratory features in ethnically homogeneous Korean patients.
Methods
We enrolled 201 SLE patients with available clinical data at the time of onset of SLE from the lupus cohort at Chonnam National University Hospital. Sociodemographic, clinical, and laboratory data, including autoantibodies, and concomitant diseases were found at the time of diagnosis of SLE by reviewing patient charts. We divided SLE patients according to age at SLE diagnosis into three groups: juvenile-onset SLE (JSLE, diagnosed at ≤ 18 years), adult-onset SLE (ASLE, diagnosed at 19–50 years), and late-onset SLE (LSLE, diagnosed at >50 years), and compared baseline demographic, clinical, and relevant laboratory findings.
Results
Of the 201 patients, 27 (14.4%), 149 (74.1%), and 25 (12.4%) were JSLE, ASLE, and LSLE patients, respectively. Fever, oral ulcers, nephritis, anemia, and thrombocytopenia were more common in JSLE patients than ASLE or LSLE patients (p < 0.05, < 0.05, 0.001, < 0.05, and < 0.05, respectively). However, Sjögren’s syndrome was more frequent in LSLE patients than JSLE or ASLE patients (p < 0.05). Disease activity was significantly higher in JSLE patients than in ASLE or LSLE patients (p < 0.001). Anti-dsDNA and anti-nucleosome antibodies were found more frequently in JSLE patients and less frequently in LSLE patients (p < 0.05 and 0.005, respectively) and decreased complement levels were more common in JSLE patients and less common in LSLE patients (p < 0.001, 0.001, and < 0.05, respectively).
Conclusions
Our results indicate that SLE patients present with different clinical and serological manifestations according to age at disease onset. JSLE patients have more severe disease activity and more frequent renal involvement and LSLE patients have milder disease activity, more commonly accompanied by Sjögren’s syndrome, at disease onset.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Age of Onset</subject><subject>Arthritis</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune diseases</subject><subject>Child</subject><subject>Disease</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Laboratories</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Patients</subject><subject>Republic of Korea - epidemiology</subject><subject>Rheumatology</subject><subject>Serology</subject><subject>Severity of Illness Index</subject><subject>Sjogren's Syndrome - epidemiology</subject><subject>Sociodemographics</subject><subject>Young Adult</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kU-LFDEQxYMo7rh69yQBLx5srSST7s5RBv_hghc9N-lOZcyQTtokLcxX8FObdlaRBS9VVOr3XgoeIU8ZvGKs616DahkHIZiUigHf3yM7tu-6pr7z-2S3rZttf0Ue5XwCAMFU-5Bc8Rb6KpE78vMQ50Unl2Og0dLJu-Am7akOhmZM0cfj79k4azFhmDBTPcdwpKf1BwbnsXlJtVl92XoVeV2wiSFjofmcC85uon5d1kwxncs3nHWJuU4u0E8xoQ500cVhKPkxeWC1z_jktl-Tr-_efjl8aG4-v_94eHPTTHvBSq1KsI6B7ZWREweJIFCOFhCsHgWzRgvVSYGt7EaAnoPBCUYuQe07Y1pxTV5cfJcUv6-YyzC7PKH3OmBc81DNRUU5qIo-v4Oe4ppCvW6jZK94L3ml4EJNKeac0A5LcrNO54HBsOU03M2pSp7dGq_jjOav4E8wFWguQNZH_OfX_xn-As8bm1c</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Choi, J H</creator><creator>Park, D J</creator><creator>Kang, J H</creator><creator>Yim, Y R</creator><creator>Lee, K E</creator><creator>Lee, J W</creator><creator>Wen, L</creator><creator>Kim, T J</creator><creator>Park, Y W</creator><creator>Lee, J K</creator><creator>Lee, S S</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients</title><author>Choi, J H ; Park, D J ; Kang, J H ; Yim, Y R ; Lee, K E ; Lee, J W ; Wen, L ; Kim, T J ; Park, Y W ; Lee, J K ; Lee, S S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-c4931710f89d5c205e03e5bf0e0fab31fda39753e657b00820dec0b250947dd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Age of Onset</topic><topic>Arthritis</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune diseases</topic><topic>Child</topic><topic>Disease</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Laboratories</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Patients</topic><topic>Republic of Korea - epidemiology</topic><topic>Rheumatology</topic><topic>Serology</topic><topic>Severity of Illness Index</topic><topic>Sjogren's Syndrome - epidemiology</topic><topic>Sociodemographics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, J H</creatorcontrib><creatorcontrib>Park, D J</creatorcontrib><creatorcontrib>Kang, J H</creatorcontrib><creatorcontrib>Yim, Y R</creatorcontrib><creatorcontrib>Lee, K E</creatorcontrib><creatorcontrib>Lee, J W</creatorcontrib><creatorcontrib>Wen, L</creatorcontrib><creatorcontrib>Kim, T J</creatorcontrib><creatorcontrib>Park, Y W</creatorcontrib><creatorcontrib>Lee, J K</creatorcontrib><creatorcontrib>Lee, S S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, J H</au><au>Park, D J</au><au>Kang, J H</au><au>Yim, Y R</au><au>Lee, K E</au><au>Lee, J W</au><au>Wen, L</au><au>Kim, T J</au><au>Park, Y W</au><au>Lee, J K</au><au>Lee, S S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>24</volume><issue>12</issue><spage>1342</spage><epage>1349</epage><pages>1342-1349</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract><![CDATA[Objectives
We investigated whether systemic lupus erythematosus (SLE) patients could be distinguished based on the time of disease onset and, if so, whether the groups differed in their clinical and laboratory features in ethnically homogeneous Korean patients.
Methods
We enrolled 201 SLE patients with available clinical data at the time of onset of SLE from the lupus cohort at Chonnam National University Hospital. Sociodemographic, clinical, and laboratory data, including autoantibodies, and concomitant diseases were found at the time of diagnosis of SLE by reviewing patient charts. We divided SLE patients according to age at SLE diagnosis into three groups: juvenile-onset SLE (JSLE, diagnosed at ≤ 18 years), adult-onset SLE (ASLE, diagnosed at 19–50 years), and late-onset SLE (LSLE, diagnosed at >50 years), and compared baseline demographic, clinical, and relevant laboratory findings.
Results
Of the 201 patients, 27 (14.4%), 149 (74.1%), and 25 (12.4%) were JSLE, ASLE, and LSLE patients, respectively. Fever, oral ulcers, nephritis, anemia, and thrombocytopenia were more common in JSLE patients than ASLE or LSLE patients (p < 0.05, < 0.05, 0.001, < 0.05, and < 0.05, respectively). However, Sjögren’s syndrome was more frequent in LSLE patients than JSLE or ASLE patients (p < 0.05). Disease activity was significantly higher in JSLE patients than in ASLE or LSLE patients (p < 0.001). Anti-dsDNA and anti-nucleosome antibodies were found more frequently in JSLE patients and less frequently in LSLE patients (p < 0.05 and 0.005, respectively) and decreased complement levels were more common in JSLE patients and less common in LSLE patients (p < 0.001, 0.001, and < 0.05, respectively).
Conclusions
Our results indicate that SLE patients present with different clinical and serological manifestations according to age at disease onset. JSLE patients have more severe disease activity and more frequent renal involvement and LSLE patients have milder disease activity, more commonly accompanied by Sjögren’s syndrome, at disease onset.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26085595</pmid><doi>10.1177/0961203315591024</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 2015-10, Vol.24 (12), p.1342-1349 |
| issn | 0961-2033 1477-0962 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1713947209 |
| source | Sage Journals Online |
| subjects | Adolescent Adult Age Age Factors Age of Onset Arthritis Autoantibodies - blood Autoimmune diseases Child Disease Ethnicity Female Hospitals Humans Internal medicine Laboratories Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - epidemiology Male Middle Aged Nervous system Patients Republic of Korea - epidemiology Rheumatology Serology Severity of Illness Index Sjogren's Syndrome - epidemiology Sociodemographics Young Adult |
| title | Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T18%3A18%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20clinical%20and%20serological%20differences%20among%20juvenile-,%20adult-,%20and%20late-onset%20systemic%20lupus%20erythematosus%20in%20Korean%20patients&rft.jtitle=Lupus&rft.au=Choi,%20J%20H&rft.date=2015-10-01&rft.volume=24&rft.issue=12&rft.spage=1342&rft.epage=1349&rft.pages=1342-1349&rft.issn=0961-2033&rft.eissn=1477-0962&rft_id=info:doi/10.1177/0961203315591024&rft_dat=%3Cproquest_cross%3E3816138781%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c431t-c4931710f89d5c205e03e5bf0e0fab31fda39753e657b00820dec0b250947dd63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1715892852&rft_id=info:pmid/26085595&rft_sage_id=10.1177_0961203315591024&rfr_iscdi=true |