Weak Coordination Promoted Regioselective Oxidative Coupling Reaction for 2,2′-Difunctional Biaryl Synthesis in Hexafluoro-2-propanol

An unprecedented weak coordination promoted dehydrogenative cross-coupling reaction has been developed by palladium catalysis, which provides a convenient access to a wide range of 2,2′-difunctional biaryls from easily accessible substrates. Both HFIP solvent and oxidants serve as the critical facto...

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Bibliographic Details
Published in:Organic letters 2015-09, Vol.17 (18), p.4456-4459
Main Authors: Zhang, Chao, Rao, Yu
Format: Article
Language:English
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Summary:An unprecedented weak coordination promoted dehydrogenative cross-coupling reaction has been developed by palladium catalysis, which provides a convenient access to a wide range of 2,2′-difunctional biaryls from easily accessible substrates. Both HFIP solvent and oxidants serve as the critical factors in this new reaction. A plausible mechanism involving Pd­(II)/Pd­(IV) is proposed. The reaction demonstrates excellent reactivity, broad functional-group tolerance and high yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b02115