In vivo identification of pancreatic cystic neoplasms with needle-based confocal laser endomicroscopy

• Published in: Baillière's best practice & research. Clinical gastroenterology 2015-08, Vol.29 (4), p.601-610
• Main Authors: Tsujino, Takeshi, MD, PhD, Yan-Lin Huang, Jason, MD, Nakai, Yosuke, MD, PhD, Samarasena, Jason B., MD, Lee, John G., MD, Chang, Kenneth J., MD
• Format: Article
• Language: English
• Subjects: Accuracy; Acquisitions & mergers; Antigens; Catheters; Clinical medicine; Confidence intervals; Confocal laser endomicroscopy; Cysts; Endoscopic ultrasonography; Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods; Endoscopy; Fine-needle aspiration; Gastroenterology and Hepatology; Humans; Medical imaging; Microscopy, Confocal - instrumentation; Neoplasms, Cystic, Mucinous, and Serous - diagnosis; Pancreatic Cyst - diagnosis; Pancreatic cystic lesions; Pancreatic Neoplasms - diagnosis; Surveillance; Tumors
• ISSN: 1521-6918; 1532-1916
• DOI: 10.1016/j.bpg.2015.06.006

Abstract Pancreatic cystic lesions (PCLs) are increasingly identified with the widespread use of imaging modalities. The precise diagnosis of PCLs remains a challenge despite the use of CT, MRI, and EUS-FNA. Confocal laser endomicroscopy (CLE) is a new endoscopic imaging modality that provides real-time, very high magnification images. A smaller CLE probe, which can be passed through a 19-gauge FNA needle, is now available. Needle-based CLE during EUS has recently been examined to evaluate PLCs, and the specific criteria of nCLE for the diagnosis of PLCs have been proposed.