Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study

• Published in: Tissue antigens 2015-10, Vol.86 (4), p.276-278
• Main Authors: Angelo, H. D., Gomes Silva, I. I. F., Oliveira, R. D. R., Louzada-Júnior, P., Donadi, E. A., Crovella, S., Maia, M. M. D., de Souza, P. R. E., Sandrin-Garcia, P.
• Format: Article
• Language: English
• Subjects: Adult; Alleles; arthritis; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - pathology; Brazil; Case-Control Studies; cytokines; Female; Gene Expression; Gene Frequency; Genetic Predisposition to Disease; Humans; Interferon-gamma - genetics; Interferon-gamma - immunology; Interleukin-12 Subunit p40 - genetics; Interleukin-12 Subunit p40 - immunology; Interleukin-18 - genetics; Interleukin-18 - immunology; Male; Middle Aged; Pilot Projects; Polymerase Chain Reaction; polymorphism; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; rheumatoid; Risk
• ISSN: 0001-2815; 1399-0039
• DOI: 10.1111/tan.12645

Polymorphisms in interleukin (IL)‐18, IL‐12 and interferon (IFN)‐γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL‐18 +105 A/C, IL‐12B +1188 A/C and IFN‐γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism‐polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL‐18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P