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Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study
Polymorphisms in interleukin (IL)‐18, IL‐12 and interferon (IFN)‐γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL‐18 +105 A/C, IL‐12B +1188 A/C and IFN‐γ +874 T/A polymorphisms were analyzed by restriction fragment lengt...
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| Published in: | Tissue antigens 2015-10, Vol.86 (4), p.276-278 |
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| container_title | Tissue antigens |
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| creator | Angelo, H. D. Gomes Silva, I. I. F. Oliveira, R. D. R. Louzada-Júnior, P. Donadi, E. A. Crovella, S. Maia, M. M. D. de Souza, P. R. E. Sandrin-Garcia, P. |
| description | Polymorphisms in interleukin (IL)‐18, IL‐12 and interferon (IFN)‐γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL‐18 +105 A/C, IL‐12B +1188 A/C and IFN‐γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism‐polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL‐18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P |
| doi_str_mv | 10.1111/tan.12645 |
| format | article |
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D. ; Gomes Silva, I. I. F. ; Oliveira, R. D. R. ; Louzada-Júnior, P. ; Donadi, E. A. ; Crovella, S. ; Maia, M. M. D. ; de Souza, P. R. E. ; Sandrin-Garcia, P.</creator><creatorcontrib>Angelo, H. D. ; Gomes Silva, I. I. F. ; Oliveira, R. D. R. ; Louzada-Júnior, P. ; Donadi, E. A. ; Crovella, S. ; Maia, M. M. D. ; de Souza, P. R. E. ; Sandrin-Garcia, P.</creatorcontrib><description>Polymorphisms in interleukin (IL)‐18, IL‐12 and interferon (IFN)‐γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL‐18 +105 A/C, IL‐12B +1188 A/C and IFN‐γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism‐polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL‐18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P < 0.0001). Individual carriers of the variant allele C had a 3.77‐fold increased risk of for RA (P = 0.0032). No association was observed for IL‐12B and IFN‐γ polymorphisms. Our finds suggest a possible role for IL‐18 polymorphism in the RA susceptibility in studied population.</description><identifier>ISSN: 0001-2815</identifier><identifier>EISSN: 1399-0039</identifier><identifier>DOI: 10.1111/tan.12645</identifier><identifier>PMID: 26302971</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Alleles ; arthritis ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - pathology ; Brazil ; Case-Control Studies ; cytokines ; Female ; Gene Expression ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Interferon-gamma - genetics ; Interferon-gamma - immunology ; Interleukin-12 Subunit p40 - genetics ; Interleukin-12 Subunit p40 - immunology ; Interleukin-18 - genetics ; Interleukin-18 - immunology ; Male ; Middle Aged ; Pilot Projects ; Polymerase Chain Reaction ; polymorphism ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; rheumatoid ; Risk</subject><ispartof>Tissue antigens, 2015-10, Vol.86 (4), p.276-278</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4335-7358b270921f40db43128a5a3f8c627375c6251e04956f053eac1e8b47e65dd63</citedby><cites>FETCH-LOGICAL-c4335-7358b270921f40db43128a5a3f8c627375c6251e04956f053eac1e8b47e65dd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26302971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Angelo, H. D.</creatorcontrib><creatorcontrib>Gomes Silva, I. I. F.</creatorcontrib><creatorcontrib>Oliveira, R. D. R.</creatorcontrib><creatorcontrib>Louzada-Júnior, P.</creatorcontrib><creatorcontrib>Donadi, E. A.</creatorcontrib><creatorcontrib>Crovella, S.</creatorcontrib><creatorcontrib>Maia, M. M. D.</creatorcontrib><creatorcontrib>de Souza, P. R. E.</creatorcontrib><creatorcontrib>Sandrin-Garcia, P.</creatorcontrib><title>Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study</title><title>Tissue antigens</title><addtitle>Tissue Antigens</addtitle><description>Polymorphisms in interleukin (IL)‐18, IL‐12 and interferon (IFN)‐γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL‐18 +105 A/C, IL‐12B +1188 A/C and IFN‐γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism‐polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL‐18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P < 0.0001). Individual carriers of the variant allele C had a 3.77‐fold increased risk of for RA (P = 0.0032). No association was observed for IL‐12B and IFN‐γ polymorphisms. Our finds suggest a possible role for IL‐18 polymorphism in the RA susceptibility in studied population.</description><subject>Adult</subject><subject>Alleles</subject><subject>arthritis</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Brazil</subject><subject>Case-Control Studies</subject><subject>cytokines</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Interferon-gamma - genetics</subject><subject>Interferon-gamma - immunology</subject><subject>Interleukin-12 Subunit p40 - genetics</subject><subject>Interleukin-12 Subunit p40 - immunology</subject><subject>Interleukin-18 - genetics</subject><subject>Interleukin-18 - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Polymerase Chain Reaction</subject><subject>polymorphism</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>rheumatoid</subject><subject>Risk</subject><issn>0001-2815</issn><issn>1399-0039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kMtO3TAQhi1UBKeURV-g8rJIDfgS20l33EE6ompFxdLySSYcQ-IE2xGcbvtIfY8-E4YA6qazGc3om1-aD6GPlOzSVHvRuF3KZC7W0IzysswI4eU7NCOE0IwVVGyi9yHcpClXZbmBNpnkhJWKztDvcxfBtzDeWpfR4gu2_87sABtXT7sGfO-yv3_wNTjAQ9-uut4PSxu6kAB84M0v21rj8GCiBRcDvrdxif0Sxs7E3tbY-Lj0NtrwFRs82LaPOMSxXn1A641pA2y_9C308-T48vAsm387PT_cn2dVzrnIFBfFgilSMtrkpF7knLLCCMObopJMcSVSExRIXgrZEMHBVBSKRa5AirqWfAt9nnIH39-NEKLubKigbY2DfgyaqiRP0FyyhO5MaOX7EDw0evC2M36lKdFPznVyrp-dJ_bTS-y46KB-I18lJ2BvAu5tC6v_J-nL_YvXyGy6sCHCw9uF8bdaPj2qry5O9fcT-kMezYlW_BH-k5ub</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Angelo, H. D.</creator><creator>Gomes Silva, I. I. F.</creator><creator>Oliveira, R. D. R.</creator><creator>Louzada-Júnior, P.</creator><creator>Donadi, E. A.</creator><creator>Crovella, S.</creator><creator>Maia, M. M. D.</creator><creator>de Souza, P. R. E.</creator><creator>Sandrin-Garcia, P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study</title><author>Angelo, H. D. ; Gomes Silva, I. I. F. ; Oliveira, R. D. R. ; Louzada-Júnior, P. ; Donadi, E. A. ; Crovella, S. ; Maia, M. M. D. ; de Souza, P. R. E. ; Sandrin-Garcia, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4335-7358b270921f40db43128a5a3f8c627375c6251e04956f053eac1e8b47e65dd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>arthritis</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Brazil</topic><topic>Case-Control Studies</topic><topic>cytokines</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Interferon-gamma - genetics</topic><topic>Interferon-gamma - immunology</topic><topic>Interleukin-12 Subunit p40 - genetics</topic><topic>Interleukin-12 Subunit p40 - immunology</topic><topic>Interleukin-18 - genetics</topic><topic>Interleukin-18 - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Polymerase Chain Reaction</topic><topic>polymorphism</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>rheumatoid</topic><topic>Risk</topic><toplevel>online_resources</toplevel><creatorcontrib>Angelo, H. D.</creatorcontrib><creatorcontrib>Gomes Silva, I. I. F.</creatorcontrib><creatorcontrib>Oliveira, R. D. R.</creatorcontrib><creatorcontrib>Louzada-Júnior, P.</creatorcontrib><creatorcontrib>Donadi, E. A.</creatorcontrib><creatorcontrib>Crovella, S.</creatorcontrib><creatorcontrib>Maia, M. M. D.</creatorcontrib><creatorcontrib>de Souza, P. R. E.</creatorcontrib><creatorcontrib>Sandrin-Garcia, P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue antigens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Angelo, H. D.</au><au>Gomes Silva, I. I. F.</au><au>Oliveira, R. D. R.</au><au>Louzada-Júnior, P.</au><au>Donadi, E. A.</au><au>Crovella, S.</au><au>Maia, M. M. D.</au><au>de Souza, P. R. E.</au><au>Sandrin-Garcia, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study</atitle><jtitle>Tissue antigens</jtitle><addtitle>Tissue Antigens</addtitle><date>2015-10</date><risdate>2015</risdate><volume>86</volume><issue>4</issue><spage>276</spage><epage>278</epage><pages>276-278</pages><issn>0001-2815</issn><eissn>1399-0039</eissn><abstract>Polymorphisms in interleukin (IL)‐18, IL‐12 and interferon (IFN)‐γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL‐18 +105 A/C, IL‐12B +1188 A/C and IFN‐γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism‐polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL‐18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P < 0.0001). Individual carriers of the variant allele C had a 3.77‐fold increased risk of for RA (P = 0.0032). No association was observed for IL‐12B and IFN‐γ polymorphisms. Our finds suggest a possible role for IL‐18 polymorphism in the RA susceptibility in studied population.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>26302971</pmid><doi>10.1111/tan.12645</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Alleles arthritis Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Brazil Case-Control Studies cytokines Female Gene Expression Gene Frequency Genetic Predisposition to Disease Humans Interferon-gamma - genetics Interferon-gamma - immunology Interleukin-12 Subunit p40 - genetics Interleukin-12 Subunit p40 - immunology Interleukin-18 - genetics Interleukin-18 - immunology Male Middle Aged Pilot Projects Polymerase Chain Reaction polymorphism Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide rheumatoid Risk |
| title | Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study |
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