A Metal- and Azide-Free Multicomponent Assembly toward Regioselective Construction of 1,5-Disubstituted 1,2,3-Triazoles

The construction of 1,5-disubstituted 1,2,3-triazoles has been effected through the cascade dual C–N bond formation, N–N bond formation and an acyl migration-based C–C bond formation via the three-component reactions of enaminones, tosylhydrazine and primary amines. This metal- and azide-free, regio...

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Bibliographic Details
Published in:Journal of organic chemistry 2015-09, Vol.80 (18), p.9028-9033
Main Authors: Wan, Jie-Ping, Cao, Shuo, Liu, Yunyun
Format: Article
Language:English
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Summary:The construction of 1,5-disubstituted 1,2,3-triazoles has been effected through the cascade dual C–N bond formation, N–N bond formation and an acyl migration-based C–C bond formation via the three-component reactions of enaminones, tosylhydrazine and primary amines. This metal- and azide-free, regioselective synthetic method proceeds in the presence of only molecular iodine.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b01121