Colostrum quality affects immune system establishment and intestinal development of neonatal calves

• Published in: Journal of dairy science 2015-10, Vol.98 (10), p.7153-7163
• Main Authors: Yang, M., Zou, Y., Wu, Z.H., Li, S.L., Cao, Z.J.
• Format: Article
• Language: English
• Subjects: Animals; Animals, Newborn - growth & development; Animals, Newborn - immunology; Cattle; colostrum; Colostrum - physiology; Duodenum - anatomy & histology; Female; Ileum - anatomy & histology; immune and antioxidant; Immunization, Passive; Immunoglobulin G - blood; Immunoglobulin G - immunology; immunoglobulin G absorption; intestinal development; Intestinal Mucosa - anatomy & histology; Intestine, Small - anatomy & histology; Intestine, Small - growth & development; Intestines - growth & development; Jejunum - anatomy & histology; Male; neonatal calf; Peyer's Patches; Pregnancy; Superoxide Dismutase - blood
• ISSN: 0022-0302; 1525-3198
• DOI: 10.3168/jds.2014-9238

The first meal of a neonatal calf after birth is crucial for survival and health. The present experiment was performed to assess the effects of colostrum quality on IgG passive transfer, immune and antioxidant status, and intestinal morphology and histology in neonatal calves. Twenty-eight Holstein neonatal male calves were used in the current study, 24 of which were assigned to 1 of 3 treatment groups: those that received colostrum (GrC), transitional milk (GrT, which was obtained after the first milking on 2–3 d after calving), and bulk tank milk (GrB) only at birth. The 4 extra neonatal calves who were not fed any milk were assigned to the control group and were killed immediately after birth to be a negative control to small intestinal morphology and histology detection. Calves in GrC gained more body weight than in GrT, whereas GrB calves lost 0.4kg compared with the birth weight. Serum total protein, IgG, and superoxide dismutase concentrations were highest in GrC, GrT was intermediate, whereas GrB was the lowest on d 2, 3, and 7. Apparent efficiency of absorption at 48 h, serum complement 3 (C3), and complement 4 (C4) on d 2, 3, and 7 in GrB was low compared with GrC and GrT. On the contrary, malondialdehyde on d 7 increased in GrB. Calves in GrC had better villus length and width, crypt depth, villus height/crypt depth (V/C) value, and mucosal thickness in the duodenum, jejunum, and ileum, whereas GrT calves had lower villus length and width, crypt depth, and mucosal thickness than those fed colostrum. Villi of calves in GrB were nonuniform, sparse, severely atrophied, and apically abscised, and Peyer’s patches and hydroncus were detected. Overall, colostrum is the best source for calves in IgG absorption, antioxidant activities, and serum growth metabolites, and promoting intestinal development. The higher quality of colostrum calves ingested, the faster immune defense mechanism and the more healthy intestinal circumstances they established.