Maternal VDR variants rather than 25-hydroxyvitamin D concentration during early pregnancy are associated with type 1 diabetes in the offspring

Aims/hypothesis We investigated whether single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentration in the metabolic pathway of vitamin D show different genotype distributions between Finnish families with an offspring with type 1 diabetes (cases) and families with a hea...

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Bibliographic Details
Published in:Diabetologia 2015-10, Vol.58 (10), p.2278-2283
Main Authors: Miettinen, Maija E., Smart, Melissa C., Kinnunen, Leena, Mathews, Christopher, Harjutsalo, Valma, Surcel, Heljä-Marja, Lamberg-Allardt, Christel, Tuomilehto, Jaakko, Hitman, Graham A.
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Child
Child, Preschool
Cytochrome
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - genetics
Families & family life
Female
Genes
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Human Physiology
Humans
Infant
Infant, Newborn
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Mothers
Polymorphism, Single Nucleotide
Pregnancy
Receptors, Calcitriol - genetics
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin deficiency
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Summary:Aims/hypothesis We investigated whether single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentration in the metabolic pathway of vitamin D show different genotype distributions between Finnish families with an offspring with type 1 diabetes (cases) and families with a healthy offspring (controls). Methods A total of 31 SNPs in eight genes were studied in case and control mothers and family members (offspring with type 1 diabetes and healthy siblings, healthy control children and fathers) ( n  = 2,854). The 25-hydroxyvitamin D concentration was studied in 474 case and 348 matched control mothers during pregnancy. Results The genotype distributions of 13 SNPs (in the following genes: 7-dehydrocholesterol reductase NADSYN1/DHCR7 , vitamin D receptor VDR , group-specific component GC and CYP27A1 ) that showed a nominal association with 25-hydroxyvitamin D concentration ( p  
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-015-3675-8