Antibody-mediated thrombosis: Relation to the antiphospholipid syndrome

Various forms of antibody-mediated thrombosis are presented and the mechanisms involved in their pathogenesis are discussed. Antibody-mediated thrombosis includes heparin-induced thrombocytopenia and thrombosis, autoantibodies to von Willebrand factor mimicking an antiphospholipid syndrome, thrombos...

Full description

Saved in:
Bibliographic Details
Published in:Lupus 1998-01, Vol.7 (2_suppl), p.63-66
Main Authors: Vermylen, J, Geet, C Van, Arnout, J
Format: Article
Language:English
Subjects:
Adult
Animals
Antibodies, Viral - immunology
Antibody Specificity
Antiphospholipid Syndrome - immunology
Autoantibodies - immunology
Autoimmune Diseases - immunology
Chickenpox - complications
Chickenpox - immunology
Child
Cross Reactions
Graft Rejection - immunology
Heparin - adverse effects
Herpes Zoster - immunology
Humans
Mammals - immunology
Molecular Mimicry
Muromonab-CD3 - adverse effects
Muromonab-CD3 - immunology
Protein S - immunology
Protein S Deficiency - etiology
Receptors, Fc - immunology
Thrombocytopenia - chemically induced
Thrombocytopenia - immunology
Thrombosis - chemically induced
Thrombosis - immunology
Transplantation, Heterologous - immunology
von Willebrand Factor - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Various forms of antibody-mediated thrombosis are presented and the mechanisms involved in their pathogenesis are discussed. Antibody-mediated thrombosis includes heparin-induced thrombocytopenia and thrombosis, autoantibodies to von Willebrand factor mimicking an antiphospholipid syndrome, thrombosis following injection of the murine monoclonal antibody OKT3, hyperacute and acute xenograft rejection, and varicella-associated antibody against protein S. In several of these entities the pathogenesis of thrombosis is closely related to development of cellular procoagulant activity through tight occupancy of Fc receptors, or through complement activation, or through cell-cell interactions. Integrating the antiphospholipid syndrome into the more general category of antibody-mediated thrombosis may provide some hints as to how we could approach the study of those intriguing patients who have the clinical features of the antiphospholipid syndrome but lack those antibodies that currently characterize it.
ISSN:0961-2033
1477-0962
DOI:10.1177/096120339800700215