KCNQ/Kv7 Channel Regulation of Hippocampal Gamma-Frequency Firing in the Absence of Synaptic Transmission

1 Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol School of Medical Sciences, Bristol; and 2 Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom Submitted 13 October 2005; accepted in fi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurophysiology 2006-05, Vol.95 (5), p.3105-3112
Main Authors: Piccinin, S, Randall, A. D, Brown, J. T
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Action Potentials - radiation effects
Animals
Anthracenes - pharmacology
Calcium - metabolism
Carbamates - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Electric Stimulation - methods
Hippocampus - cytology
Hippocampus - physiology
In Vitro Techniques
Indoles - pharmacology
KCNQ Potassium Channels - physiology
Male
Neurons - drug effects
Neurons - physiology
Neurons - radiation effects
Periodicity
Phenylenediamines - pharmacology
Potassium - metabolism
Potassium - pharmacology
Potassium Channel Blockers - pharmacology
Pyridines - pharmacology
Rats
Synaptic Transmission - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1 Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol School of Medical Sciences, Bristol; and 2 Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom Submitted 13 October 2005; accepted in final form 2 February 2006 Synchronous neuronal firing can be induced in hippocampal slices in the absence of synaptic transmission by lowering extracellular Ca 2+ and raising extracellular K + . However, the ionic mechanisms underlying this nonsynaptic synchronous firing are not well understood. In this study we have investigated the role of KCNQ / Kv7 channels in regulating this form of nonsynaptic bursting activity. Incubation of rat hippocampal slices in reduced (
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.01083.2005