Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer

Ambs et al examined whether nitric oxide generated by nitric oxide synthase is capable of inducing mutations in the p53 gene and whether this contributes to human colorectal cancer.

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1999-01, Vol.91 (1), p.86-88
Main Authors: AMBS, S, BENNETT, W. P, MERRIAM, W. G, OGUNFUSIKA, M. O, OSER, S. M, HARRINGTON, A. M, SHIELDS, P. G, FELLEY-BOSCO, E, HUSSAIN, S. P, HARRIS, C. C
Format: Article
Language:English
Subjects:
Adenoma - enzymology
Adenoma - genetics
Biological and medical sciences
Carcinoma - enzymology
Carcinoma - genetics
Colonic Polyps - enzymology
Colonic Polyps - genetics
Colorectal cancer
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - genetics
CpG Islands
DNA Mutational Analysis
DNA, Neoplasm - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Genes
Genes, p53
Humans
Medical sciences
Models, Biological
Mutagenesis
Mutation
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Nitric Oxide - metabolism
Nitric Oxide Synthase - biosynthesis
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase Type II
Nitrogen
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Description
Summary:Ambs et al examined whether nitric oxide generated by nitric oxide synthase is capable of inducing mutations in the p53 gene and whether this contributes to human colorectal cancer.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/91.1.86