Overexpression of PI3K-p110α in the progression of uterine cervical neoplasia and its correlation with pAkt and DJ-1

• Published in: European journal of gynaecological oncology 2015, Vol.36 (4), p.389-393
• Main Authors: Choi, S K, Hong, Y O, Lee, W M, Kim, E K, Joo, J E, Kim, D W, Lee, H
• Format: Article
• Language: English
• Subjects: Class Ia Phosphatidylinositol 3-Kinase - analysis; Class Ia Phosphatidylinositol 3-Kinase - physiology; Disease Progression; Female; HSP90 Heat-Shock Proteins - physiology; Humans; Intracellular Signaling Peptides and Proteins - analysis; Intracellular Signaling Peptides and Proteins - physiology; Oncogene Proteins - analysis; Oncogene Proteins - physiology; Protein Deglycase DJ-1; Proto-Oncogene Proteins c-akt - analysis; Proto-Oncogene Proteins c-akt - physiology; PTEN Phosphohydrolase - analysis; Uterine Cervical Neoplasms - pathology
• ISSN: 0392-2936
• DOI: 10.12892/ejgo2591.2015

To investigate the expression of PI3K-p110α, pAkt, PTEN, the signaling molecules from PI3K/Akt signaling pathway, DJ-1, an oncoprotein and HSP90a, a molecular chaperone, and their correlation in uterine cervical neoplasia, in order to elucidate their role in cervical carcinogenesis. Using immunohistochemistry, the authors analyzed the expression of PI3K-p110α, pAkt, PTEN, DJ-1 and HSP90α, and their correlation in ten normal tissues, cervical intraepithelial neoplasia (CIN) including 30 CIN1 and 31 CIN3, and 33 cases of invasive squamous cell carcinoma (SCC). The expression of all proteins significantly increased in CIN3 compared to CIN1, and only the expression of PI3K-p110α significantly increased in invasive SCC compared to CIN3. There was a significant positive correlation between the expression of PI3K-p110α and DJ-1, as well as PI3K-p110α and pAkt in CIN3 and invasive SCC. Overexpression of PI3K-p110α is associated with progression of uterine cervical neoplasia, and the expression of pAkt and DJ-1 is positively correlated with PI3K-p110α expression in this process.