Sensitivity of rainbow trout leucocytes to aflatoxin B

In vitro exposure of rainbow trout (Oncorhynchus mykiss) peripheral blood leucocytes to aflatoxin B sub(1) (AFB sub(1)) leads to a dramatic suppression of immunological function as indicated by decreased lymphocyte proliferation and immunoglobulin production in response to the mitogen lipopolysaccha...

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Bibliographic Details
Published in:Fish & shellfish immunology 1998-10, Vol.8 (7), p.515-530
Main Authors: Ottinger, CA, Kaattari, S L
Format: Article
Language:English
Subjects:
Oncorhynchus mykiss
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Summary:In vitro exposure of rainbow trout (Oncorhynchus mykiss) peripheral blood leucocytes to aflatoxin B sub(1) (AFB sub(1)) leads to a dramatic suppression of immunological function as indicated by decreased lymphocyte proliferation and immunoglobulin production in response to the mitogen lipopolysaccharide. These leucocytes were up to 1000-fold more sensitive to this carcinogen than were murine leucocytes. Additionally, leucocytes procured from trout during July-December were significantly (P=0 times 01) more sensitive to AFB sub(1) than those obtained during January-June. Immunosuppression was observed with AFB sub(1) concentrations that were not toxic as measured by cell viability. This decrease in AFB sub(1) sensitivity appears to occur subsequent to a generalised winter-associated period of decreased immune reactivity that has been observed in a number of ectothermic species and in this study.
ISSN:1050-4648