Adiposity affects human response to inhaled organic dust

Background Swine containment facilities are often highly contaminated with organic dusts that often contain varying levels of endotoxins and other microbial products. This study was performed to evaluate the effect of obesity on the inflammatory response induced by chronic or acute exposure to swine...

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Bibliographic Details
Published in:American journal of industrial medicine 2006-04, Vol.49 (4), p.281-285
Main Authors: Cormier, Yvon, Israël-Assayag, Evelyne
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adolescent
Adult
Air
Air Pollutants, Occupational - adverse effects
air pollution
Animal Husbandry
Animals
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - analysis
Case-Control Studies
Dust
Environmental pollutants toxicology
Humans
inflammation
Intercellular Adhesion Molecule-1 - blood
Interleukin-6 - blood
Interleukin-8 - blood
L-Selectin - blood
Male
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Obesity - blood
Occupational Exposure - adverse effects
organic dust
pig farmers
Swine
Toxicology
Tumor Necrosis Factor-alpha - analysis
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Summary:Background Swine containment facilities are often highly contaminated with organic dusts that often contain varying levels of endotoxins and other microbial products. This study was performed to evaluate the effect of obesity on the inflammatory response induced by chronic or acute exposure to swine confinement buildings (SCB). Methods Two separate studies were performed; Study I included 36 SCB long‐time workers and a control group of 35 matched male hospital workers never exposed to SCB. In Study II, 14 naïve healthy young subjects (8 overweight and 6 lean) volunteered to be acutely exposed to a SCB environment for 5 hr. Markers of sub‐clinical inflammation linked to obesity (C‐reactive protein (CRP), interleukin 6 (IL‐6)) or to active inflammation (soluble adhesion molecules, IL‐8, TNF) were measured. Results In the first study, positive correlations were found between girth circumference and serum levels of IL‐6 (r = 0.57, P = 0.0003) and CRP (r = 0.62, P 
ISSN:0271-3586
1097-0274
DOI:10.1002/ajim.20265