Influence of D‐arabitol and ribitol on neuronal network activity

Summary To date, two new defects in the pentose phosphate pathway have been identified in patients with abnormalities in their polyol profiles. Some of them presented with neurological symptoms of so far unknown aetiology. The pathophysiological role of polyols, e.g. in the brain, is relatively unkn...

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Bibliographic Details
Published in:Journal of inherited metabolic disease 2005-12, Vol.28 (6), p.1181-1183
Main Authors: Klusmann, A., Fleischer, W., Waldhaus, A., Siebler, M., Mayatepek, E.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - metabolism
Carbohydrate Metabolism
Cryopreservation
Dose-Response Relationship, Drug
Electrophysiology
Humans
Lidocaine - pharmacology
Medical genetics
Medical sciences
Metabolic diseases
Nerve Net
Neurons - metabolism
Rats
Ribitol - metabolism
Sugar Alcohols - metabolism
Tetrodotoxin - pharmacology
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Summary:Summary To date, two new defects in the pentose phosphate pathway have been identified in patients with abnormalities in their polyol profiles. Some of them presented with neurological symptoms of so far unknown aetiology. The pathophysiological role of polyols, e.g. in the brain, is relatively unknown. We tested the neurotoxicity of polyols using a ‘neurochip’ model. After exposure of cortical rat neurons to D‐arabitol and ribitol in increasing concentrations up to 10 mmol/L, the electrophysiological activity was measured. No acute effect on the spontaneous network activity of cortical neurons was observed. We speculate that polyols have only secondary effects on brain dysfunction.
ISSN:0141-8955
1573-2665
DOI:10.1007/s10545-005-0073-2