Genetic algorithm for optimization and specification of a neuron model

We present a novel approach for neuron model specification using a genetic algorithm (GA) to develop simple firing neuron models consisting of a single compartment with one inward and one outward current. The GA not only chooses the model parameters, but also chooses the formulation of the ionic cur...

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Bibliographic Details
Published in:Neurocomputing (Amsterdam) 2006-06, Vol.69 (10), p.1039-1042
Main Authors: Gerken, W.C., Purvis, L.K., Butera, R.J.
Format: Article
Language:English
Subjects:
Genetic algorithm
Model specification
Morris–Lecar
Neuron model
Parameter optimization
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Summary:We present a novel approach for neuron model specification using a genetic algorithm (GA) to develop simple firing neuron models consisting of a single compartment with one inward and one outward current. The GA not only chooses the model parameters, but also chooses the formulation of the ionic currents (i.e. single-state variable, two-state variable, instantaneous, or leak). The fitness function of the GA compares the frequency output of the GA-generated models to an I– F curve of a nominal Morris–Lecar (ML) model. Initially, several different classes of models compete within the population. Eventually, the GA converges to a population containing only ML-type firing models, that is, models with an instantaneous inward and single-state variable outward current. Simulations where ML-type models are restricted from the population are also investigated. This GA approach allows the exploration of a universe of feasible model classes that is less constrained by model formulation assumptions than traditional parameter estimation approaches.
ISSN:0925-2312
1872-8286
DOI:10.1016/j.neucom.2005.12.041