Differential expression of α-synuclein splice variants in the brain of alcohol misusers: Influence of genotype

Highlights • The expression of SNCA -140 and SNCA -112 was significantly lower and the expression of SNCA -115 was significantly greater in cirrhotic alcohol misusers than in controls. • The allele and genotype frequencies for three SNPs (rs356221, rs356219 and rs2736995) differed significantly betw...

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Bibliographic Details
Published in:Drug and alcohol dependence 2015-10, Vol.155, p.284-292
Main Authors: Janeczek, Paulina, Brooker, Corinne, Dodd, Peter R, Lewohl, Joanne M
Format: Article
Language:English
Subjects:
3′-UTR
Alcoholism - complications
Alcoholism - genetics
Alcoholism - metabolism
Alleles
alpha-Synuclein - biosynthesis
alpha-Synuclein - genetics
Case-Control Studies
European Continental Ancestry Group - genetics
Gene Expression - genetics
Genetic Variation - genetics
Genotype
Haplotype
Haplotypes
Human
Humans
Linkage Disequilibrium - genetics
Liver Cirrhosis, Alcoholic - complications
Liver Cirrhosis, Alcoholic - genetics
Liver Cirrhosis, Alcoholic - metabolism
Polymorphism, Single Nucleotide - genetics
Prefrontal cortex
Prefrontal Cortex - metabolism
Protein Isoforms - biosynthesis
Protein Isoforms - genetics
Psychiatry
SNCA
Variants
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Summary:Highlights • The expression of SNCA -140 and SNCA -112 was significantly lower and the expression of SNCA -115 was significantly greater in cirrhotic alcohol misusers than in controls. • The allele and genotype frequencies for three SNPs (rs356221, rs356219 and rs2736995) differed significantly between alcohol misusers and controls. • Results suggest that the rs356219/356221 G-A haplotype may decrease the chance of having an alcohol misuse phenotype. • Sequence variation in the 3′-UTR of the gene did not affect the expression of α-synuclein splice variants. • SNPs were not significantly associated with α-synuclein gene expression in our population.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2015.05.045