Higher Red Blood Cell Distribution Width Is an Adverse Prognostic Factor in Chronic-phase Chronic Myeloid Leukemia Patients Treated with Tyrosine Kinase Inhibitors

The significance of red blood cell distribution width (RDW) was evaluated in patients with chronic myeloid leukemia (CML) in the chronic phase (CP). Eighty-four patients with newly-diagnosed CML-CP treated with any tyrosine kinase inhibitor (TKI) were analyzed. Patients were divided into two groups:...

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Bibliographic Details
Published in:Anticancer research 2015-10, Vol.35 (10), p.5473-5478
Main Authors: Iriyama, Noriyoshi, Hatta, Yoshihiro, Kobayashi, Sumiko, Uchino, Yoshihito, Miura, Katsuhiro, Kurita, Daisuke, Kodaira, Hitomi, Takahashi, Hiromichi, Iizuka, Yoshikazu, Inoue, Mitsuru, Takei, Masami
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Erythrocytes - drug effects
Erythrocytes - pathology
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology
Middle Aged
Protein Kinase Inhibitors - administration & dosage
Protein Kinase Inhibitors - therapeutic use
Retrospective Studies
Survival Analysis
Treatment Outcome
Young Adult
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Summary:The significance of red blood cell distribution width (RDW) was evaluated in patients with chronic myeloid leukemia (CML) in the chronic phase (CP). Eighty-four patients with newly-diagnosed CML-CP treated with any tyrosine kinase inhibitor (TKI) were analyzed. Patients were divided into two groups: a low-RDW group (RDW values ≤15%, n=31) and a high-RDW group (RDW values >15%, n=53). The 5-year event-free survival (EFS) and transformation-free survival (TFS) rates differed significantly between the low- and high-RDW groups (100% and 68%, respectively, in EFS, p=0.0071 and 100% and 81%, respectively, in TFS, p=0.039). The stratification by RDW had an impact on overall 5-year survival (100% in the low and 77% in the high RDW groups, p=0.047). We conclude that the RDW has a critical role in risk stratification of CML-CP patients for predicting treatment responses and outcomes.
ISSN:1791-7530