Exploring the applicability of analysing X chromosome STRs in Brazilian admixed population

Abstract Kinship and parentage analyses always involve one sample being compared to another sample or a few samples with a specific relationship question in mind. In most cases, the analysis of autosomal STR markers is sufficient to determine the genetic kinship. However, when genetic profiles are r...

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Bibliographic Details
Published in:Science & justice 2015-09, Vol.55 (5), p.323-328
Main Authors: Auler-Bittencourt, Eloisa, Iwamura, Edna Sadayo Miazato, Lima, Maria Jenny Mitraud, da Silva, Ismael Dale Cotrim Guerreiro, dos Santos, Sidney Emannuel Batista
Format: Article
Language:English
Subjects:
Brazil
Brazilian population
Chromosomes
Chromosomes, Human, X
Criminal justice
DNA Fingerprinting - methods
Female
Forensic cases
Forensic medicine
Forensic sciences
Gene Frequency
Genetic kinship
Genetic Markers
Genotype
Humans
Likelihood Functions
Male
Microsatellite Repeats
Pathology
Pedigree
Rape
Software
STR-Chr X
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Summary:Abstract Kinship and parentage analyses always involve one sample being compared to another sample or a few samples with a specific relationship question in mind. In most cases, the analysis of autosomal STR markers is sufficient to determine the genetic kinship. However, when genetic profiles are reconstructed from supposed relatives, for whom the family configuration available for analysis is deficient, the examination may be inconclusive. This study reports practical examples of actual cases analysing the efficiency of the chromosome X STR (STR-ChrX) markers. Three cases with different degrees of efficiency and impact were selected as follows: the identification of two charred bodies in a traffic accident, in which the family setting available was not complete, and one filiation analysis resulting from rape. This is the first paper reporting the use of the multiplex STR 12 ChrX in actual cases using the software Familias 1.8 and Brazilian regional frequency data. Our study clarifies the complex analysis using this powerful tool for professionals in the forensic science community, for both civil and criminal justice. We also discuss state-of-the-art ChrX STR markers and its implications and applications for legal procedures. The data presented here should be used in other studies of complex cases to improve the progress of the current justice system.
ISSN:1355-0306
1876-4452
DOI:10.1016/j.scijus.2015.03.004