Ferroptosis： a novel cell death form will be promising therapy target for diseases

Recently, Friedmann Angeli et al. [1] reported that the loss of ferroptosis regulation enzyme glutathione peroxidase 4 （GPX4） will cause an overwhelming ferroptosis of renal cells, which eventually induces renal failure. Yet, liproxstatin-1, a novel potent ferroptosis inhibitor, is able to alleviate...

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Bibliographic Details
Published in:Acta biochimica et biophysica Sinica 2015-10, Vol.47 (10), p.857-859
Main Authors: Wu, Di, Chen, Linxi
Format: Article
Language:English
Subjects:
Animals
Cell Death
Humans
Iron - metabolism
弗里德曼
治疗
研究人员
神经疾病
细胞死亡
缺血/再灌注损伤
肾功能衰竭
谷胱甘肽过氧化物酶
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Summary:Recently, Friedmann Angeli et al. [1] reported that the loss of ferroptosis regulation enzyme glutathione peroxidase 4 （GPX4） will cause an overwhelming ferroptosis of renal cells, which eventually induces renal failure. Yet, liproxstatin-1, a novel potent ferroptosis inhibitor, is able to alleviate tissue injury of ischemia/reperfusion-indnced renal injury. This study smartly expanded the research on nonapoptotic cell death, ferroptosis, as researchers were just focused on its effect on tumor and neuronal diseases before [2,3].
ISSN:1672-9145
1745-7270
DOI:10.1093/abbs/gmv086