Possible neural substrates of beer-craving in rats

Rats voluntarily consumed beer in a distinctive environment during 30 min daily sessions over 21 days, ingesting a daily average of 0.96 g/kg of ethanol. On a final test day, rats in a `craving' condition were denied access to the beer in the drinking environment. The expression of c-fos in the...

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Bibliographic Details
Published in:Neuroscience letters 1998-08, Vol.252 (2), p.99-102
Main Authors: Topple, Ann N, Hunt, Glenn E, McGregor, Iain S
Format: Article
Language:English
Subjects:
Alcoholism - physiopathology
Anatomical correlates of behavior
Animals
Anxiety
Anxiety - chemically induced
Anxiety - metabolism
Beer
Behavior, Animal - drug effects
Behavioral psychophysiology
Biological and medical sciences
Brain Chemistry - drug effects
C-fos
Central Nervous System Stimulants - pharmacology
Craving
Ethanol
Ethanol - pharmacology
Fundamental and applied biological sciences. Psychology
Male
Neurons - drug effects
Neurons - physiology
Proto-Oncogene Proteins c-fos - analysis
Proto-Oncogene Proteins c-fos - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat
Rats
Rats, Wistar
Self Administration
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Summary:Rats voluntarily consumed beer in a distinctive environment during 30 min daily sessions over 21 days, ingesting a daily average of 0.96 g/kg of ethanol. On a final test day, rats in a `craving' condition were denied access to the beer in the drinking environment. The expression of c-fos in the brain of `craving' rats was compared with that in rats given free access on the test day (`beer' condition), and to rats which had been repeatedly placed in the drinking environment without ever having access to beer (`control' condition). Rats in the `craving' condition showed significantly higher c-fos counts than either the `beer' or `control' rats in a variety of corticolimbic and brainstem structures, indicating that activation of these regions occurs when a desirable alcoholic beverage is expected but not received.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(98)00574-6