Prescription of enoxaparin is associated with decreasing pulmonary embolism mortality rate in Germany

• Published in: Journal of thrombosis and thrombolysis 2015-11, Vol.40 (4), p.468-473
• Main Authors: Pütter, Carolin, von Beckerath, Olga, Sobik, Hanna Maria, Reinecke, Holger, Stausberg, Jürgen, Kröger, Knut
• Format: Article
• Language: English
• Subjects: Cardiology; Drug Prescriptions; Enoxaparin - administration & dosage; Female; Germany - epidemiology; Hematology; Humans; Male; Medicine; Medicine & Public Health; Pulmonary Embolism - drug therapy; Pulmonary Embolism - mortality; Survival Rate
• ISSN: 0929-5305; 1573-742X
• DOI: 10.1007/s11239-015-1265-8

We analysed time trends in the pulmonary embolism (PE) mortality rates in Germany from 2004 and assessed for an association between the use of anticoagulants and PE caused mortality. We extracted age-specific number of deaths due to PE (ICD-10 I26) from 2004 to 2011 as available from the WHO mortality databases. In addition we derived defined daily dosage (DDD) of prescribed anticoagulants and the low molecular heparin Enoxaparin for the years 2004–2011 from the statutory health insurance-drug-information system reports. Age-standardized PE mortality per 100,000 decreased from 5.9283 in year 2004 to 4.4876 in 2011 (−24.3 %). Amounts of prescribed anticoagulants increased in this period from 271,810.7 × 1000 DDD to 416,611.8 × 1000 DDD (+53.3 %), that of Enoxaparin increased from 27,071.1 × 1000 DDD in 2004 97,276.5 × 1000 DDD in 2011. The PE mortality is negatively correlated with anticoagulants (−0.9463, p = 0.0004) as well as with enoxaparin (−0.9740, p