Qualitative analysis of an ethanolic extract from Trametes versicolor and biological screening against Leishmania amazonensis

This study was carried out with basidiomycete mushroom Trametes versicolor. The fruiting body of the mentioned mushroom was extracted with alcohol and submitted to a qualitative phytochemical screening for secondary metabolites identification. This experiment afforded the presence of secondary metab...

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Bibliographic Details
Published in:Emirates journal of food and agriculture 2015-07, Vol.27 (7), p.592-592
Main Authors: Leliebre-Lara, Vivian, García, Marley, Nogueiras, Clara, Monzote, Lianet
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Basidiomycetes
Cancer
Conflicts of interest
Cytotoxicity
Drug dosages
Drugs
Ethanol
Flavonoids
Leishmania amazonensis
Metabolites
Molecular weight
Mushrooms
Parasites
Parasitic diseases
Phytochemicals
Steroids
Toxicity
Trametes versicolor
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Summary:This study was carried out with basidiomycete mushroom Trametes versicolor. The fruiting body of the mentioned mushroom was extracted with alcohol and submitted to a qualitative phytochemical screening for secondary metabolites identification. This experiment afforded the presence of secondary metabolites kind of triterpenes, steroids, flavonoids, alkaloids, and in a small amount cardenolides. Quinones were not found within tested metabolites. In addition, extracts of this mushroom fresh fruiting body of different polarity (ranging from n-hexane, dichloromethane, ethyl acetate until ethanol) were evaluated against promastigotes of Leishmania amazonensis, a widespread tropical and subtropical disease produced by around 20 species of protozoa from Leishmania genus. The ethyl acetate and the ethanol extract exhibited anti-leishmanial activity, with IC^sub 50^ values of 101.8 ± 4.2 μg/mL and 97.4 ± 2.0 μg/mL, respectively. The cytotoxicity against peritoneal macrophage from BALB/c mice from those extracts was reported.
ISSN:2079-052X
2079-0538
DOI:10.9755/ejfa.2015.05.194