Butyrolactones derivatives from the fermentation products of a plant entophytic fungus Penicillium oxalicum

Two new butyrolactone derivatives, terrelactones A and B (1 and 2), together with four known butyrolactone derivatives (3-6), were isolated from the fermentation products of the fungus Penicillium oxalicum 0403. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D...

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Bibliographic Details
Published in:Natural product research 2015-10, Vol.29 (20), p.1914-1919
Main Authors: Yuan, Lin, Huang, Wenzhong, Zhou, Kun, Wang, Yuede, Dong, Wei, Du, Gang, Gao, Xuemei, Ma, Yinhai, Hu, Qiufen
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - chemistry
4-Butyrolactone - isolation & purification
anti-TMV activities
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
butyrolactone derivatives
Fermentation
Lactones - chemistry
Lactones - isolation & purification
Molecular Structure
Penicillium - chemistry
Penicillium oxalicum
Penicillium oxalicum 0403
Tobacco Mosaic Virus - drug effects
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Summary:Two new butyrolactone derivatives, terrelactones A and B (1 and 2), together with four known butyrolactone derivatives (3-6), were isolated from the fermentation products of the fungus Penicillium oxalicum 0403. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1 and 2 were evaluated. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 25.5% and 27.4%, respectively. The inhibition rate is close to that of positive control (28.9%).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2015.1013473