Small Angular Mhc Co-expressing Fibers In Copd Muscle: Evidence Of Premature Aging?

To investigate whether MHC co-expressing fibers in peripheral muscle of COPD patients exhibit features of long-term denervation. A muscle biopsy of the vastus lateralis was collected from three severe COPD patients (65+1y, FEV1=37.7+1.5 %pred) to investigate fiber size, fiber circularity (calculated...

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Published in:Medicine and science in sports and exercise 2012-05, Vol.44 (5S), p.681-681
Main Authors: Kapchinsky, Sophia, MacMillan, Norah J, Purves-Smith, Fennigje M, Sgarioto, Nicolas, Baril, Jacinthe, Mainguy, Vincent, Provencher, Steve, Jagoe, Thomas, Taivassalo, Tanja, Hepple, Russell
Format: Article
Language:English
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Summary:To investigate whether MHC co-expressing fibers in peripheral muscle of COPD patients exhibit features of long-term denervation. A muscle biopsy of the vastus lateralis was collected from three severe COPD patients (65+1y, FEV1=37.7+1.5 %pred) to investigate fiber size, fiber circularity (calculated as 4[pi] x area/perimeter2, where a perfect circle = 1.0), and fiber type using immunolabelling for type I, IIa, and IIx MHC isoforms. For comparison, a biopsy was also collected from a healthy agematched subject (CTRL; 64 y). Fiber size distribution in COPD muscle showed a pronounced leftward shift towards an increased abundance of smaller fibers compared to CTRL. Similarly, COPD patients also exhibited a leftward shift towards less circular fibers, and in contrast to the CTRL subject, exhibited several very angular fibers (circularity [< or =] 0.4) with a very low cross-sectional area ([< or =]2000um2). All but one of these small angular fibers was co-expressing MHC IIa and IIx.
ISSN:0195-9131