Fetuin-A Responses to Incremental Weight Loss

The objectives of this investigation were to characterize the effects of incremental weight loss on circulating concentrations of fetuin-A and to determine relationships between fetuin-A and changes in body composition in obese men. Sixteen obese men (age = 43.3 + 9.0; weight = 106.5 + 17.8 kg; BMI...

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Published in:Medicine and science in sports and exercise 2012-05, Vol.44 (5S), p.609-609
Main Authors: Grandjean, Peter W, Ren, Guang, He, Xiaoming, Kim, Teayoun, Littlefield, Laurel A, Bowers, Robert L, Araya-Ramirez, Felipe, Mahurin, A Jack, Mathews, Suresh T
Format: Article
Language:English
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Summary:The objectives of this investigation were to characterize the effects of incremental weight loss on circulating concentrations of fetuin-A and to determine relationships between fetuin-A and changes in body composition in obese men. Sixteen obese men (age = 43.3 + 9.0; weight = 106.5 + 17.8 kg; BMI = 33.4 + 4.4 kg/m2; body fat = 36 + 4%) were assigned to regularly-practiced exercise and dietary restriction in order to reach a targeted weight loss of 8 to 10% of initial body weight over a 6 to 10-month period. Fetuin-A was significantly reduced with 2-4% weight loss (83 mg/mL or 18.7%) and decreased by 126 mg/mL or 28.5% with target weight loss (p = 0.0002). Markers of insulin sensitivity [HOMA and glucose/insulin ratio, reported previously: MSSE Vol. 43 (5) No. 2462, 2011] were improved with as little as 4-6% weight-loss (p 0.05).
ISSN:0195-9131